Validation of a Deep Learning Tool for Opportunistic Osteoporosis Screening Using Routine Non-Contrast CT Scans

Enrolling by invitation

Conditions studied: Osteoporosis

In brief

The goal of this clinical trial is to test if an artificial intelligence (AI) tool called DeepBMD can accurately identify people at high risk for osteoporosis using routine chest or abdomen CT scans. The main questions it aims to answer are: 1. Can the DeepBMD tool correctly identify people who have osteoporosis compared to the standard bone density test, dual-energy X-ray absorptiometry (DXA)? 2. Is it practical to use this AI tool in real-world hospital settings to find and contact high-risk patients? Researchers will use the DeepBMD tool to analyze existing CT scans. If the tool flags a patient as high risk, researchers will call them to invite them for a standard bone density test (DXA). Participants will: 1. Have their existing chest or abdomen CT scan analyzed by the DeepBMD AI tool; 2. Receive a phone call from the research team if identified as high risk; 3. Visit the clinic for a free standard bone density test (DXA) if they agree to participate.

Key facts

Study ID

NCT07739628

Run by

Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

People needed

100

Starts

2026-07-01

Expected to finish

2026-09-01

Last updated by the study team

2026-07-31

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Underwent non-contrast CT at our institution, with qualified image quality and no severe artifacts;
• Identified as high-risk for osteoporosis by the DeepBMD model;
• Had valid contact information available in the PACS, possessed normal cognitive and communication abilities, and was able to cooperate with telephone follow-ups and on-site examinations;
• Voluntarily participated in the study, was able to sign a written informed consent form on-site, and agreed to undergo DXA examination.

You may not qualify if…

• Severe spinal deformity, postoperative spinal internal fixation, malignant bone metastasis, or severe osteolytic lesions that may interfere with measurements;
• A confirmed diagnosis of osteoporosis with ongoing standardized treatment;
• Inability to be contacted, explicit refusal of follow-up, or inability to visit the hospital for informed consent signing and DXA examination.

Where it is running

• Union Hospital, Tongji Medical College, Huazhong University of Science and Technology — Wuhan, Hubei, China

Full record on ClinicalTrials.gov

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