Mechanisms Underlying Late-Life Prolonged Grief Disorder
Starting soon · Not applicable
Conditions studied: Prolonged Grief Disorder
In brief
After losing a loved one, most successfully navigate acute grief and adapt to the loss within about 1 year, but in about 10%, prolonged grief disorder (PGD) ensues. This study is anticipated to provide novel evidence regarding the neurobiological mechanisms of PGD in older adults. The biological alterations identified here could provide targets to elucidate how currently available therapies work and inform novel mechanism-based interventions for treating late-life PGD.
Key facts
- Study ID
- NCT07738133
- Run by
- Medical College of Wisconsin
- People needed
- 126
- Starts
- 2027-01-01
- Expected to finish
- 2031-06-01
- Last updated by the study team
- 2026-07-31
Who can join
Age: 40 and older, up to 89. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Male or female greater than or equal to 40 years of age
- Bereavement >6 months
- Score greater than or equal to 25 on the Inventory of Complicated Grief (ICG)
- Presence of PGD (subsyndromal and syndromal)
- Adequate visual and auditory acuity
You may not qualify if…
- Delirium/unstable medical conditions
- Lifetime history of neurological illnesses: seizures, stroke, dementia of any -etiology, severe head injury, brain tumor or surgery
- Serious back, joint or neck injuries within the past 3 months
- Currently practicing yoga
- Gross structural abnormalities on T1-weighted images
- Lifetime history of the following psychiatric disorders: bipolar or psychotic -disorders, including psychotic depression
- Current alcohol/drug abuse or dependence
- Magnetic resonance imaging (MRI) contraindications
- Acute suicidality
Where it is running
- Medical College of Wisconsin — Milwaukee, Wisconsin, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.