Lactic Acid Bacteria for Reducing Blue Light-Induced Eye Fatigue

Starting soon · Not applicable · Has a placebo group

Conditions studied: Digital Eye Strain (DES)

In brief

With the widespread use of digital devices and prolonged screen exposure, digital eye strain (DES), also known as computer vision syndrome, has become a global public health concern. Emerging evidence suggests that the gut-eye axis may play an important role in ocular health, as gut microbiota imbalance is associated with systemic inflammation and oxidative stress. Specific probiotics may help alleviate eye discomfort through modulation of immune responses and enhancement of antioxidant defense mechanisms. This randomized, double-blind, placebo-controlled study aims to evaluate the efficacy of supplementation with specific probiotics, Bifidobacterium longum BL531 and Lactobacillus reuteri LR1349, in improving digital eye strain symptoms in adults.

Key facts

Study ID

NCT07737938

Run by

Synbio Tech Inc.

People needed

150

Starts

2026-09-01

Expected to finish

2027-12-31

Last updated by the study team

2026-07-30

Who can join

Age: 20 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Men and women aged 20-65 years
• Daily digital screen use >6 hours for at least 1 year
• Mild to severe digital eye strain (CVS-Q score ≥ 6)
• Mild to moderate dry eye symptoms (OSDI ≥ 13)

You may not qualify if…

• Amblyopia or strabismus
• Severe eye diseases (e.g., glaucoma , cataract , retinal disorders, severe corneal disease)
• Ocular surgery within the past 12 months
• Chronic systemic diseases (e.g., uncontrolled diabetes, autoimmune disease, severe liver/kidney impairment, cancer)
• Recent use (<1 months) of steroids, antibiotics, immunosuppressants, probiotics, prebiotics, or eye-health supplements
• Pregnant or breastfeeding
• Allergy to probiotics or study product ingredients
• Eating disorders, psychiatric illness, or cognitive impairment affecting compliance
• Any condition judged unsuitable by the investigator

Where it is running

• National Taiwan Normal University — Taipei, Taiwan

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.