Acute Effects of Estradiol Administration on Brain Function During Fear Learning

Starting soon · Early Phase 1

Conditions studied: PTSD and Trauma-related Symptoms, Cognitive Decline in Older Adults, Post Menopausal Women

In brief

The goal of current study is to better understand how fear is processed in the brain and how these processes are influenced by cognition and hormones. This research will focus specifically on postmenopausal female adults, because age-related changes in cognition and declining estrogen levels may contribute to anxiety symptoms and PTSD risk later in life.

Key facts

Study ID

NCT07737613

Run by

University of Arizona

People needed

30

Starts

2026-08-01

Expected to finish

2027-12-01

Last updated by the study team

2026-07-30

Who can join

Age: 60 and older. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• post-menopausal
• normal or corrected-to-normal vision
• English speaking
• stable medication use (no changes in the past three months)

You may not qualify if…

• use of hormone therapy containing synthetic estrogen
• MRI contraindications (e.g., irremovable ferrous metal in body, claustrophobia)
• history of neurological disorder (including mild cognitive impairment) or moderate to severe traumatic brain injury
• use of antipsychotic, opiate, or mood stabilizer (i.e., lithium) medication
• history of blood clots/deep vein thrombosis, prior stroke or TIA, uncontrolled hypertension
• history of migraine with aura
• severe liver disease
• history of breast, endometrial, or ovarian cancer
• smoking >10 cigarettes/day

Full record on ClinicalTrials.gov

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