Association of Lipoprotein(a) With Postoperative Atrial Fibrillation

Starting soon

Conditions studied: POAF, Atrial Fibrillation (AF)

In brief

About one in three patients who undergo open-heart surgery develop an irregular heart rhythm called postoperative atrial fibrillation (POAF). This condition increases the risk of stroke, prolongs hospital stays, and raises the chances of complications and death compared with patients who do not develop it. Because of these serious outcomes, researchers are working to identify which patients are most at risk. One potential blood marker is lipoprotein(a), or Lp(a). Higher levels of Lp(a) have been linked to abnormal heart rhythms in previous studies. We want to determine whether patients with elevated Lp(a) are more likely to develop POAF after heart surgery and better understand the biological mechanisms behind this risk. In this study, patients will be grouped based on whether they have high or low Lp(a) levels. All participants will wear a chest band monitor that continuously tracks heart rhythm for 3 months after surgery to detect POAF. During surgery, small tissue samples from the heart will also be collected. By examining these samples, we will assess whether patients with elevated Lp(a) show more scarring and inflammation which are two pathways known to cause abnormal heart rhythms. The goal of this study is to determine whether elevated Lp(a) increases susceptibility to POAF. This could help identify patients who may benefit from preventive treatments and closer monitoring. By understanding how Lp(a) affects heart tissue, we also hope to uncover the mechanisms that contribute to abnormal rhythm and guide the development of future targeted therapies to treat POAF and other heart rhythms.

Key facts

Study ID

NCT07737444

Run by

Anthony Tang

People needed

20

Starts

2026-09-01

Expected to finish

2028-09-01

Last updated by the study team

2026-08-03

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥18 years
• Scheduled for elective or urgent CABG, valve replacement, or combined CABG and valve replacement
• Willing to wear the Skiin chest band for the duration of the study
• Have a smartphone with an Operating System compatible with the
• Skiin Connected Life App (Android 9+ or iOS 13+)

You may not qualify if…

• Emergency indication for CABG, valve replacement, or combined CABG and valve replacement
• Prior cardiac surgery
• History of pre-operative persistent atrial fibrillation

Full record on ClinicalTrials.gov

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