Discontinuation One Week Recommendations for GLP-1 Receptor Agonists Prior to Esophagogastroduodenoscopy.
Recruiting now · Phase 3
Conditions studied: GLP-1
In brief
This study aims to evaluate the impact of a one-week discontinuation of long-acting glucagon-like peptide-1 receptor agonists (GLP-1 RAs) prior to Esophagogastroduodenoscopy on gastric preparation quality and the need for repeat esophagogastroduodenoscopy (EGD), in order to determine whether a one-week drug interruption constitutes an appropriate pre-procedural recommendation.
Key facts
- Study ID
- NCT07736911
- Run by
- Fu Jen Catholic University Hospital
- People needed
- 140
- Starts
- 2026-06-01
- Expected to finish
- 2030-06-01
- Last updated by the study team
- 2026-07-30
Who can join
Age: 18 and older, up to 90. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- • Current use of GLP-1 receptor agonists (GLP-1 RAs) or tirzepatide (defined as discontinuation for no more than one week).
- Continuous GLP-1 RA use for at least 4 weeks, or treatment at a near-maximal maintenance dose.
- Scheduled to undergo esophagogastroduodenoscopy (EGD) for any indication.
- Age between 18 and 70 years.
- Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.
- Provision of written informed consent.
- Outpatient status.
- If currently receiving medications that stimulate or inhibit gastrointestinal motility, these agents must be discontinued at least 3 days prior to EGD.
You may not qualify if…
- • Severe comorbid conditions precluding safe EGD (e.g., unstable angina, recent myocardial infarction, heart failure, chronic respiratory disease, or bleeding diathesis).
- History of prior upper gastrointestinal resection (stomach, intestine, or esophagus).
- Any other condition deemed inappropriate by the treating physician.
- Body mass index (BMI) > 40 kg/m².
- Liver cirrhosis.
- Parkinson's disease.
- Dementia.
- Use of tricyclic antidepressants or opioid medications for more than 3 months.
Where it is running
- FJUH — New Taipei City, Taiwan, Taiwan (enrolling)
Full record on ClinicalTrials.gov
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