Drospirenone-Primed Ovarian Stimulation Versus GnRH Antagonist Protocol in Poor Ovarian Responders Undergoing Freeze-All IVF/ICSI

Starting soon · Phase 1/Phase 2

Conditions studied: Poor Ovarian Reserve, Infertility (IVF Patients)

In brief

Participants will: * Take either drospirenone (a daily pill) or the standard daily injection during their ovarian stimulation cycle, alongside their regular fertility hormone injections * Undergo egg retrieval, with all resulting embryos frozen (no fresh embryo transfer in this study) * Have a frozen embryo transferred in a later cycle * Complete two short questionnaires about their treatment experience - once before starting the injections/pills, and once after the stimulation phase ends * Be followed to determine if the embryo transfer results in a pregnancy

Key facts

Study ID

NCT07736261

Run by

Ahmed Saad

People needed

100

Starts

2026-08-01

Expected to finish

2027-11-01

Last updated by the study team

2026-07-30

Who can join

Age: 20 and older, up to 42. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Spontaneous menstrual cycles (21-35 days)
• Poor ovarian response per Bologna criteria (≥2 of 3): advanced age ≥40 or risk factor for POR; previous poor response (≤3 oocytes with conventional stimulation); abnormal ovarian reserve (AFC <7 or AMH <1.1 ng/mL)
• POSEIDON group recorded at enrollment (1-4) for stratified randomization and pre-specified subgroup description - corrects a known limitation of Bologna-only classification, which pools biologically distinct POR phenotypes
• Indication for IVF/ICSI
• Willing and able to undergo mandatory freeze-all/FET protocol
• Signed informed consent, including explicit acknowledgment that fresh transfer is not offered in either study arm

You may not qualify if…

• Contraindication to ovarian stimulation
• Known müllerian anomaly
• Uncontrolled systemic disease
• 5 prior failed IVF attempts
• Known contraindication to drospirenone (per product labeling, e.g., renal impairment, adrenal insufficiency, conditions predisposing to hyperkalemia)

Where it is running

• Hawaa Fertility Center — Banhā, Qalyubia Governorate, Egypt

Full record on ClinicalTrials.gov

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