Effects and Mechanisms of Temporal Interference Stimulation (TIS) on Neuropathic Pain

Starting soon · Not applicable · Has a placebo group

Conditions studied: Neuropathic Pain, tTIS

In brief

This study employs temporal interference stimulation (tTIS) to investigate the analgesic effects of tTIS on neuropathic pain and monitor changes in neural plasticity, and explore the dynamic relationship between analgesic efficacy and neural plasticity, thereby providing new strategies for the treatment of neuropathic pain.

Key facts

Study ID

NCT07735975

Run by

Second Affiliated Hospital, Zhejiang University, School of Medicine

People needed

60

Starts

2026-08-01

Expected to finish

2028-01-31

Last updated by the study team

2026-07-30

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• IASP diagnosis of peripheral neuropathic pain;
• At least one month after the onset of pain;
• At least moderate pain intensity (≥ 3 assessed by VAS or NRS);
• 18 years or older;
• Stable medical treatment from 2 weeks before allocation to the end of the trial;
• Willing to receive TIS treatment and capable of fulfilling clinical assessments.

You may not qualify if…

• Contradictions to TIS treatment, such as metal implants or seizure;
• Serious psychiatric disorder (Hamilton Depression Rating Scale score ≥ 35 or Hamilton Anxiety Rating Scale score ≥ 29);
• Aphasia or cognitive disorders (Mini mental state examination ≤ 24);
• Severe clinical disorders caused by tumor or other conditions;
• Severe cardiopulmonary dysfunction or extreme weakness;
• History of substance abuse (alcohol, drugs).

Full record on ClinicalTrials.gov

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