TRIS: Contingency Management App for Alcohol Use Disorder

Recruiting now · Not applicable

Conditions studied: Alcohol Use Disorder (AUD)

In brief

Alcohol Use Disorder (AUD) is a major public health concern associated with substantial morbidity, mortality, and impaired social and occupational functioning. Contingency Management (CM) is an evidence-based behavioral intervention that provides incentives contingent on abstinence and has demonstrated effectiveness in the treatment of substance use disorders. This study will evaluate the efficacy of Tratamento Remoto com Incentivos à Sobriedade (TRIS), a Brazilian mobile health application that integrates a smartphone app with a Bluetooth-enabled breathalyzer (BACtrack) to deliver remote CM for AUD. Participants will be randomized to receive either standard outpatient treatment plus TRIS-based CM or standard outpatient treatment with remote alcohol monitoring only. The primary objective is to determine whether TRIS-based CM increases biochemically verified alcohol abstinence compared with standard outpatient treatment alone.

Key facts

Study ID

NCT07735585

Run by

University of Sao Paulo General Hospital

People needed

130

Starts

2026-02-19

Expected to finish

2027-12-01

Last updated by the study team

2026-07-30

Who can join

Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Able to read and speak Portuguese.
• Provide signed informed consent.
• Age 18 to 70 years.
• Alcohol consumption within the past month.
• Current diagnosis of Alcohol Use Disorder (AUD).
• Seeking treatment for AUD at AME Vila Maria or Instituto Perdizes.
• Breath alcohol concentration (BrAC) of 0.00 at the time of consent.
• Own and be able to operate a smartphone with an active mobile service plan.
• Smartphone compatible with the Bluetooth frequency required for the BACtrack breathalyzer.

You may not qualify if…

• Crack cocaine use within the past 90 days.
• Any seizure episode within the past 12 months.
• Diagnosis of a psychotic disorder (DSM-5).
• Suicide attempt within the past two years.
• Any medical or psychiatric condition that may compromise safe participation, as determined by the study medical director.

Where it is running

• IPER Research Center — São Paulo, São Paulo, Brazil (enrolling)

Full record on ClinicalTrials.gov

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