Impact of Peanut Consumption on Stress, Immune Function, Inflammation, and Cardiovascular Health in High-Stress Individuals

Starting soon · Not applicable

Conditions studied: Immune System, Stress, Chronic Stress, Cardiovascular Health

In brief

The purpose of this research is to determine whether peanut consumption improves indicators of cardiovascular disease (CVD) risk in human subjects following the consumption of study foods.

Key facts

Study ID

NCT07735221

Run by

USDA, Western Human Nutrition Research Center

People needed

70

Starts

2026-09-01

Expected to finish

2028-08-01

Last updated by the study team

2026-08-03

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Males and females
• 18-65 years old
• BMI ≥ 18.5 kg/m2 and ≤ 39.9 kg/ m2
• Recruitment will be based on Perceived Stress Scale - 4 (PSS-4) score

You may not qualify if…

• Less than 18 and over 65 years old
• Pregnant or lactating women
• Adults who rely on prescription medication that may influence study variables, apart from birth control
• BMI < 18.5 kg/m2 and > 39.9 kg/m2
• Smokers who currently use tobacco- or marijuana-containing products including e-cigarettes, vape pens, pod mods, tanks, and electronic nicotine delivery devices (ENDS)
• Habitual consumption of nuts, nut butters, nut powders, nut side dishes, nut bars or other nut products
• Known food allergies (milk, eggs, fish, shellfish, tree nuts, peanuts, wheat, soybeans, sesame, corn) due to samples not prepared in a hypoallergenic environment
• Currently living in close contact with individuals who have an allergy to peanuts, in order to avoid exposing these individuals to an allergen
• Self-reported history of difficulties with blood drawing procedures including prior fainting or dizziness, or veins assessed as not suitable for four separate venipunctures by licensed phlebotomist
• Diagnosed active chronic diseases for which the individual is currently taking daily medication, including but not limited to:
• Diabetes mellitus, cardiovascular disease, cancer, gastrointestinal disorders, kidney disease, liver disease, bleeding disorders, asthma, autoimmune disorders, hypertension, osteoporosis
• Recent minor surgery (within 4 weeks) or major surgery (within 16 weeks)
• Known gallbladder disease or history of cholecystectomy
• History of gastrointestinal surgery, including gastric bypass surgery or resection
• Diagnosis of irritable bowel syndrome
• Recent antibiotic therapy (within 4 weeks)
• Recent hospitalization (within 4 weeks)
• Current participation in another research study
• Has HIV/AIDS, hepatitis, or another disease that affects the immune system
• Gives regular blood donations and is unwilling to stop during the study
• Blood Pressure ≥ 140 mmHg systolic or 90 mmHg diastolic
• Current diagnoses of an eating disorder (ex. anorexia, bulimia, etc.)
• High - very high triglyceride levels: ≥ 300 mg/dL
• Adults who are unable to consent, individuals who are not yet adults (infants, children and teenagers), pregnant women and prisoners will be excluded from participation in the study
• Participants who are unwilling to collect and transport urine, stool and saliva samples

Where it is running

• Western Human Nutrition Research Center — Davis, California, United States

Full record on ClinicalTrials.gov

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