Evaluation of Neuregulin-4 (NRG4) Levels in Obese and Non-Obese Patients With Type 2 Diabetes Mellitus

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Conditions studied: Type 2 Diabetes Mellitus (T2DM), Obesity Type 2 Diabetes Mellitus, Insulin Resistance

In brief

This prospective observational study aims to evaluate serum Neuregulin-4 (NRG4) concentrations in obese and non-obese adults with Type 2 Diabetes Mellitus (T2DM) and to investigate their association with obesity status, insulin resistance, and different antidiabetic treatment regimens. Participants will be categorized into five predefined groups according to obesity status and treatment regimen, including SGLT2 inhibitor users, non-SGLT2 oral antidiabetic therapy users, SGLT2 combination therapy users, newly diagnosed treatment-naïve patients, and healthy controls. Clinical, anthropometric, and laboratory parameters including fasting plasma glucose, HbA1c, estimated glomerular filtration rate (eGFR), body mass index, waist circumference, waist-to-hip ratio, and serum NRG4 concentrations will be evaluated. The study aims to determine whether NRG4 may serve as a novel biomarker reflecting metabolic status and treatment response in patients with T2DM.

Key facts

Study ID

NCT07734558

Run by

GÜLDEN ANATACA

People needed

125

Starts

2026-06-01

Expected to finish

2026-12-30

Last updated by the study team

2026-07-29

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age 18-65 years
• Newly diagnosed treatment-naïve T2DM
• T2DM treated for at least 6 months
• BMI >30 kg/m²
• BMI <25 kg/m²
• No pregnancy
• No breastfeeding
• No active infection
• No inflammatory disease
• Written informed consent

You may not qualify if…

• Age <18 years
• Pregnancy
• Breastfeeding
• Active infection
• Rheumatologic disease
• Refusal to participate

Where it is running

• Kanuni Sultan Süleyman Training and Research Hospital — Istanbul, Turkey (Türkiye)

Full record on ClinicalTrials.gov

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