Pelashield vs Xeroform

Starting soon · Phase 4

Conditions studied: Skin Graft

In brief

The purpose of this research study is to compare the effects (good or bad) of a new skin graft dressing (PelashieldTM) compared to the one traditionally used (Xeroform).

Key facts

Study ID

NCT07734519

Run by

Wake Forest University Health Sciences

People needed

40

Starts

2026-08-01

Expected to finish

2027-07-01

Last updated by the study team

2026-07-31

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Undergoing split-thickness skin graft harvest, with a donor site sufficiently large to allow division into two comparable halves for randomized dressing application.
• Donor site located in an area amenable to standardized photography and serial appearance assessment.
• Ability to provide informed consent.
• Willingness and ability to participate in scheduled follow-up visits for donor-site assessment, including standardized photography.
• Donor-site management expected to follow the standardized study dressing protocol for the duration of the early healing period.

You may not qualify if…

• Inability, or anticipated inability, to reliably report pain within 1hour (or in recovery room) after surgery
• Known allergy or hypersensitivity to lidocaine, silver-containing dressings, or other components of the study dressings.
• Donor sites that are too small, irregularly shaped, or anatomically unsuitable to allow division into two comparable treatment halves.
• Pre-existing skin disease at or adjacent to the donor-site region that may affect wound healing or scar appearance
• Clinical situations in which the treating surgeon anticipates that protocol-based donor-site care cannot be maintained, including cases requiring non-standard dressings or adjunctive local therapies.
• Anticipated inability to complete follow-up assessments, including inability to obtain evaluable standardized photographs at key time points.
• Severe uncontrolled systemic conditions likely to significantly impair wound healing, at the discretion of the investigator (e.g., severe immunosuppression or other conditions making reliable donor-site healing unlikely).
• Allergy to any local anesthetic
• Allergy or sensitivity to silver
• Pregnancy

Where it is running

• Atrium Health Wake Forest Baptist — Winston-Salem, North Carolina, United States

Full record on ClinicalTrials.gov

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