Immune Response to PSF in Idiopathic vs Neuromuscular Scoliosis

Starting soon

Conditions studied: Posterior Spinal Fusion, Idiopathic Scoliosis, Neuromuscular Scoliosis

In brief

The objective of this study is to evaluate the immune response to posterior spinal fusion (PSF) in patients with neuromuscular scoliosis, comparing patients with idiopathic scoliosis who undergo the same procedure. This will be accomplished using serum biomarkers of immune response. Anecdotally, it appears that patients with neuromuscular scoliosis have more fluid resuscitation needs compared to patients with idiopathic scoliosis. The proposed hypothesis of this observation is that patients with neuromuscular scoliosis have a more profound immune response compared to patients with idiopathic scoliosis, which leads to a more robust systematic inflammatory response syndrome.

Key facts

Study ID

NCT07734467

Run by

Ambrish Patel

People needed

20

Starts

2026-10-01

Expected to finish

2029-12-01

Last updated by the study team

2026-08-06

Who can join

Age: any, up to 99. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Any patient undergoing a posterior spinal fusion, regardless of age (birth to adult)
• any patient with a diagnosis of idiopathic or neuromuscular scoliosis

You may not qualify if…

• Patient taking immunomodulators (monoclonal antibodies, chemotherapeutic agents)
• chronic steroid use

Where it is running

• Nationwide Children's Hospital — Columbus, Ohio, United States

Full record on ClinicalTrials.gov

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