Efficacy, Safety, and Tolerability of Levonorgestrel Vaginal System

Starting soon · Phase 3

Conditions studied: Contraceptive Usage

In brief

The goal of this clinical trial is to learn if drug levonorgestrel vaginal ring works as a contraceptive adult and adolescent females who are able to conceive (i.e. get pregnant). It will also learn about the safety and tolerability of levonorgestrel vaginal ring. The main questions it aims to answer are: Does drug levonorgestrel vaginal ring lower the number of pregnancies with continued use? What adverse effects do participants experience by using levonorestrel vaginal ring? Researchers will count the number of pregnancies with levonorgestrel vaginal ring after a participant uses it for a year to see if the number of pregnancies is low (i.e. women and girls do not get pregnant). Participants will: Use levonorgestrel vaginal ring for 28 days (called one cycle); for a total of 14 cycles (which is a little more than year) Visit the clinic about 8 to 10 times over about 14 months for checkups and tests with an additional approximately 13 phone calls Keep a diary of their pregnancies and number of times they use additional contraceptive (e.g. condoms)

Key facts

Study ID

NCT07734155

Run by

Chemo Research

People needed

1600

Starts

2026-12-01

Expected to finish

2030-12-01

Last updated by the study team

2026-07-29

Who can join

Age: 13 and older, up to 45. Sex: female. Healthy volunteers: not accepted.

Full record on ClinicalTrials.gov

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