HPV Detection Using Self-Collected Menstrual Blood

Starting soon · Not applicable

Conditions studied: Human Papillomavirus (HPV) Infection

In brief

This study is evaluating whether human papillomavirus (HPV) can be accurately detected from self-collected menstrual blood samples. Participants who have had routine clinical HPV testing within the previous 90 days will collect a menstrual blood sample at home using a study-provided collection kit. The HPV test result from the menstrual blood sample will be compared with the participant's prior clinical HPV test result to assess agreement between the two methods. The goal is to determine whether menstrual blood collection may provide a feasible, noninvasive approach for HPV testing.

Key facts

Study ID

NCT07733557

Run by

Samantha Batman

People needed

50

Starts

2026-07-01

Expected to finish

2029-07-01

Last updated by the study team

2026-07-29

Who can join

Age: 21 and older, up to 49. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Are 21 to 49 years old.
• Are female, have not yet gone through menopause, and expect to have a menstrual period during the study.
• Have a cervix (have not had a hysterectomy that removed the cervix). Had a routine high-risk HPV (human papillomavirus) test within the past 90 days and received a valid result (positive or negative).
• Receive medical care at the participating clinic and have been identified by the study team as a possible candidate for the study.
• Can read, understand, and communicate in English.
• Are willing and able to follow study procedures, including using a menstrual blood collection kit and returning the sample for testing.
• Are willing to provide informed consent before any study procedures are performed.
• May be of any race or ethnicity.

You may not qualify if…

• Had an HPV test in the past 90 days, but the result was unclear, invalid, or could not be interpreted.
• Are currently pregnant.
• Have had a hysterectomy that removed the cervix.
• Are not currently having menstrual periods or are unable to provide a menstrual blood sample during the study period.
• Have a medical, mental health, cognitive, social, or other condition that, in the opinion of the study doctor, could make it difficult to safely participate or complete the study procedures.
• Are unable to understand the study requirements, use the collection kit, or return the sample for testing.
• Do not wish to participate, withdraw consent, or are unwilling to complete the required study procedures.
• Are taking part in another research study or have another circumstance that, in the opinion of the study team, could affect study results or participant safety.
• Are currently incarcerated.

Where it is running

• University of Virginia — Charlottesville, Virginia, United States

Full record on ClinicalTrials.gov

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