Evaluating the Effectiveness of AIT in the Treatment of Pain Related to Pancreatic Cancer

Starting soon · Not applicable

Conditions studied: Pancreatic Cancer Pain, Intrathecal Analgesic, Intrathecal Administration of the Drug, Pancreatic Carcinoma

In brief

The aim of this clinical trial is to assess the effectiveness of intratracheal analgesia on pain intensity in cancer patients, from the start of treatment up to 3 months. It will also investigate the safety of this technique. The main questions it seeks to answer are as follows: What is the impact on the use of opioid analgesics, and can this be measured? What is the quality of life? What is the quality of sleep, and can this be assessed? How does the patient's weight change? Is the patient satisfied? What is the patient's overall survival? The researchers will assess the equivalent daily dose of morphine (mg/day) between enrolment and follow-up visits, as well as the number of patients requiring an escalation of analgesic treatment. Overall quality of life score measured using the ESAS questionnaire between enrolment and follow-up visits; satisfaction assessed using a numerical satisfaction scale (0-10); sleep quality assessed using the ISI questionnaire; and the tolerability and safety of the technique assessed by monitoring adverse events. Eligible participants: Following implantation of the intrathecal pump, participants will have scheduled consultations at day 30, then at 3, 6, 9 and 12 months, with questionnaires to be completed.

Key facts

Study ID

NCT07733427

Run by

Clinique Bizet

People needed

40

Starts

2026-06-01

Expected to finish

2027-12-01

Last updated by the study team

2026-07-31

Who can join

Age: 20 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Subject aged over 20 years
• Patient with histologically confirmed pancreatic carcinoma
• Chronic cancer-related pain that is inadequately controlled by standard treatment or for whom analgesics are contraindicated.
• EMO < 120 mg/day Patients experiencing side effects: sedation, vomiting, constipation, or an allergy to morphine.
• Signed informed consent
• Participants affiliated with or eligible for a social security scheme
• Agree to complete the various study questionnaires

You may not qualify if…

• Patients under the age of 20.
• Contraindications to intratracheal analgesia
• Acute respiratory infection
• Uncontrolled coagulation disorder
• Pregnancy or breastfeeding
• Unable to comply with medical follow-up for the study.
• Adults who are legally protected, under guardianship or under a conservatorship

Where it is running

• Benkessou — Paris, France
• Bizet Clinic — Paris, France
• Clinique Bizet — Paris, France

Full record on ClinicalTrials.gov

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