Finasteride and Cutibacterium

Starting soon · Phase 4 · Has a placebo group

Conditions studied: Dihydrotestosterone, Periprosthetic Joint Infection (PJI), Cutibacterium Acnes

In brief

High levels of Testosterone causes high amounts of skin bacteria (Cutibacterium Acnes) which can go into the skin during a shoulder replacement surgery and cause a terrible infection. The goal of this experiment is to have participants take Finasteride, a medication that blocks testosterone production, for 2 weeks and evaluate the following: * Blood levels of testosterone * Amount of bacteria on the skin. Participants will: * Be assigned to take Finasteride, or a placebo (a look-alike pill with no active medicine) once daily, for 2 weeks * Have a small sample of their blood collected and their skin swabbed with a Q-tip to determine Testosterone levels and bacteria on the skin * Blood draw and skin testing will take place before starting Finasteride or the placebo (day 0) and at the end of the experiment (day 14).

Key facts

Study ID

NCT07731802

Run by

University of Washington

People needed

40

Starts

2026-08-31

Expected to finish

2027-08-31

Last updated by the study team

2026-07-28

Who can join

Age: 18 and older, up to 65. Sex: male. Healthy volunteers: accepted.

Full record on ClinicalTrials.gov

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