Pipelle Versus Manual Vacuum Aspiration Cannula for Endometrial Biopsy in Women With Abnormal Uterine Bleeding
Starting soon · Not applicable
Conditions studied: Abnormal Uterine Bleeding (AUB)
In brief
women globally, often requiring endometrial tissue sampling for accurate evaluation and diagnosis. Traditional office-based sampling techniques like Pipelle are widely used, but the disposable instruments can be relatively expensive in resource-limited settings. Manual Vacuum Aspiration (MVA) using a flexible cannula is an inexpensive, reusable alternative, but clinical data comparing its performance directly to Pipelle remains limited. The objective of this randomized clinical trial is to compare Pipelle endometrial biopsy and Manual Vacuum Aspiration (MVA) cannula in terms of sample adequacy, patient satisfaction, and post-procedure complications in women presenting with abnormal uterine bleeding. Participants will be randomly assigned to undergo endometrial sampling using either a 4 mm MVA cannula or a Pipelle device without anesthesia or cervical dilation. Samples will be analyzed for histopathological diagnosis, and outcomes such as procedure pain, adequacy of tissue, and complications will be recorded.
Key facts
- Study ID
- NCT07731581
- Run by
- University of Health Sciences Lahore
- People needed
- 80
- Starts
- 2026-08-11
- Expected to finish
- 2027-08-12
- Last updated by the study team
- 2026-07-28
Who can join
Age: 35 and older. Sex: female. Healthy volunteers: not accepted.
You may qualify if…
- Married women aged 35 years and above.
- Presentation with abnormal uterine bleeding (AUB), including but not limited to metrorrhagia, menorrhagia, or postmenopausal bleeding.
- Clinical indication for endometrial sampling for diagnostic evaluation of abnormal uterine bleeding.
- Patient fit for both MVA and Pipelle procedures, with no contraindications to either method.
You may not qualify if…
- Pregnancy or suspicion of pregnancy.
- Acute pelvic inflammatory disease or active genital tract infection.
- Current use of anticoagulant therapy or presence of bleeding disorders that pose a risk for excessive bleeding during endometrial sampling.
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.