Early Detection and IntervenTion in Heart Failure

Recruiting now · Not applicable

Conditions studied: Heart Failure (HF)

In brief

Heart failure (HF) occurs when the heart is no longer able to pump blood effectively throughout the body. This leads to symptoms that gradually worsen over time and are often mistaken for normal signs of aging. Because of its insidious onset, early detection is challenging. Both patients and healthcare professionals are often insufficiently aware of the early signs and symptoms of HF, resulting in delayed diagnosis. Consequently, timely initiation of treatments that could slow disease progression, improve quality of life, and reduce hospitalizations is often missed. Although a simple blood test measuring NT-proBNP levels can facilitate the early diagnosis of HF, it is not routinely used in clinical practice. The aim of this study is to evaluate whether a combined strategy for the early diagnosis and treatment of HF can reduce hospitalizations. This strategy includes: 1. increasing awareness of HF among patients and physicians, 2. using NT-proBNP testing for the early detection of HF in high-risk patients, and 3. promptly initiating guideline-directed HF treatment when the diagnosis is confirmed. The researchers will assess whether this strategy effectively reduces hospitalizations due to acute heart failure over an 18-month follow-up period.

Key facts

Study ID

NCT07731490

Run by

University Hospital, Basel, Switzerland

People needed

18000

Starts

2025-12-03

Expected to finish

2030-04-01

Last updated by the study team

2026-07-28

Who can join

Age: 65 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• General consent (GC) has not been rejected.
• Age ≥ 65 years.
• Elective percutaneous coronary intervention* (PCI), pulmonary vein isolation* (PVI), pacemaker implantation* (PM, no cardiac resynchronisation), transcatheter aortic valve intervention* (TAVI), major non-cardiac surgery* or presenting with tachyarrhythmia to the emergency department (ED) (without a diagnosis of HF within 24h).
• Exclusion criteria are assessed on day 1 after the procedure

You may not qualify if…

• Systolic blood pressure ≤ 95 mmHg
• Estimated glomerular filtration rate (GFR) <30 mL/min/1.73 m2.
• Dementia documented in the medical history.
• Metastatic cancer in the medical history.
• Previously enrolled in this study.
• Known HF.
• Known allergies, hypersensitivity, or intolerance to SGLT2 Inhibitors / Loop Diuretics / MRA or is excipients.
• Non-resident in the country of the recruiting site
• Incapacity of the patient to make judgements
• Patients not hospitalized overnight
• Patients requiring intensive care unit (ICU) or intermediate care (IMC) stay beyond 11:00 a.m. on the first postoperative day or any post-interventional stroke unit stay until 8:00 a.m. on the first postoperative day.
• Patients died prior to postinterventional day 1 (8:00 a.m.)
• Severe aortic or mitral stenosis

Where it is running

• University Hospital Basel — Basel, Basel, Switzerland (enrolling)
• Konkuk University Medical Center — Seoul, South Korea (enrolling)
• University Hospital Freiburg-Bad Krozingen — Freiburg im Breisgau, Germany
• Universitätsklinikum der Ruhr-Universität Bochum — Herne, Germany
• Herzzentrum Leipzig, Klinik für Innere Medizin/Kardiologie — Leipzig, Germany
• University Hospital Pisa — Pisa, Italy
• Erasmus MC Rotterdam — Rotterdam, Netherlands
• University Hospital Ramón y Cajal Madrid — Madrid, Spain
• University Hospital Lausanne — Lausanne, Lausanne, Switzerland
• KSA Kantonsspital Aarau — Aarau, Switzerland
• Cantonal Hospital Baden — Baden, Switzerland
• St. Claraspital AG — Basel, Switzerland
• University Hospital Genève — Geneva, Switzerland
• Kantonsspital Luzern — Lucerne, Switzerland
• Hospital Istituto Cardiocentro Ticino — Lugano, Switzerland
• Kantonsspital St. Gallen — Sankt Gallen, Switzerland
• Stadtspital Zürich — Zurich, Switzerland
• University Hospital Zurich — Zurich, Switzerland
• Universitätsklinik für Innere Medizin II — Vienna, Austria
• Royal Infirmary Edinburgh — Edinburgh, United Kingdom
• Queen Giovanna University Hospital — Sofia, Bulgaria

Full record on ClinicalTrials.gov

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