The Effect of Nicorandil on Rheumatoid Arthritis Patients
Starting soon · Phase 2/Phase 3 · Has a placebo group
Conditions studied: Rheumatoid Arthritis (RA)
In brief
The aim of this clinical trial is to determine whether nicorandil works in minimizing disease severity in patients with rheumatoid arthritis. The study will also assess the safety and tolerability of nicorandil. The main questions it aims to answer are: * Could nicorandil improve disease severity and symptoms of rheumatoid arthritis? * Does nicorandil lower the number of times participants need to use pain relieve medications? * Does the nicorandil improve participants functionality and ability to carry out daily activity? * Does nicorandil correct disease-associated damage and inflammation? * What side effects do participants have when taking nicorandil? Researchers will compare nicorandil to a placebo (a look-alike substance that contains no drug) to see if nicorandil works to decrease symptoms and severity of rheumatoid arthritis. Participants will: * Take nicorandil or a placebo two times daily for 3 months * Visit the clinic once every month for checkups * Keep a diary of their symptoms and the number of times they use a pain reliever
Key facts
- Study ID
- NCT07730723
- Run by
- Ain Shams University
- People needed
- 70
- Starts
- 2026-08-01
- Expected to finish
- 2027-07-01
- Last updated by the study team
- 2026-07-28
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Adult (≥18 years).
- Confirmed diagnosis with RA according to ACR/EULAR 2010 criteria.
- Moderate to severe disease activity (DAS-28 ˃ 3.2).
- Stable on conventional treatment for at least 3 months.
- Adequate kidney and liver function.
You may not qualify if…
- Other autoimmune diseases
- Poor patient compliance
- Malignancy or history of malignancy
- Pregnancy or lactation.
- Patients receiving bDMARDs or tsDMARDs.
- Hypersensitivity to nicorandil.
- Left ventricular heart failure or severe hypotension (SBP ˂100 mmHg).
- History of cardiogenic shock.
- History or active gastric ulcer.
- Use of drugs contraindicated with nicorandil (e.g., sildenafil, tadalafil, vardenafil, tricyclic antidepressants, or guanyl cyclase).
Where it is running
- Ain Shams University — Cairo, Abbasia, Egypt
Full record on ClinicalTrials.gov
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