Evaluation of Low-thermal Argon Plasma Devitalization for the Treatment of CIN 2 Versus Standard of Active Surveillance

Starting soon · Not applicable · Has a placebo group

Conditions studied: Cervical Intraepithelial Neoplasia Grade 2 (CIN2), Cervical Intraepithelial Neoplasia Grade 2, CIN2

In brief

The study aims to show that treatment with LtAPD works better than a sham treatment or simply monitoring the condition closely without active treatment ("active surveillance"), in achieving complete healing of a tissue abnormality on the cervix called CIN 2, after 6 months. This will be confirmed by examining tissue samples under a microscope (histopathological examination).

Key facts

Study ID

NCT07730645

Run by

University Hospital Tuebingen

People needed

264

Starts

2026-08-17

Expected to finish

2029-09-30

Last updated by the study team

2026-08-03

Who can join

Age: 18 and older, up to 40. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Female sex
• Age 18 - 40 years at the time of signing the informed consent
• Histologically confirmed CIN 2
• Full visibility of the entire transformation zone (Type 1 or Type 2) and entire lesion in colposcopy
• Ability to understand the nature of the clinical investigation and voluntarily signs the informed consent document prior to any study-related procedures

You may not qualify if…

• Histologically confirmed CIN other than CIN 2, or indication of (micro-) invasive cervical disease
• CIN lesions extending to the vaginal vault or suspicion of endocervical disease
• Current pregnancy or planned pregnancy within the next 6 months
• Presence of severe local inflammation or active infection
• Presence of a severe cardiovascular, neurological, psychiatric, endocrine, or hematological disease, immunocompromised condition or malignant tumor of any origin, as judged by the investigator
• Participation in an interfering clinical study, as judged by the investigator

Where it is running

• University Hospital Tuebingen, Department of Women's Health — Tübingen, Baden-Wurttemberg, Germany

Full record on ClinicalTrials.gov

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