Impact of Preoperative Oral Carbohydrate Loading on Insulin Resistance in Pediatric Cardiac Surgery Patients

Starting soon · Not applicable · Has a placebo group

Conditions studied: Cardiac Surgery, Insulin Resistance, Pediatric Cardiac Surgery

In brief

Surgical stress and preoperative fasting can induce insulin resistance, characterized by impaired cellular response to insulin and resulting hyperglycemia. In pediatric patients undergoing cardiac surgery, this metabolic stress response may negatively affect postoperative recovery. Although preoperative oral carbohydrate loading, defined as administering a carbohydrate-rich beverage before surgery rather than prolonged fasting, has demonstrated efficacy in reducing postoperative insulin resistance in adults, evidence supporting its use in pediatric cardiac surgery remains limited. This randomized controlled trial aims to determine whether preoperative oral carbohydrate loading reduces perioperative insulin resistance, as measured by the Homeostasis Model Assessment of Insulin Resistance (HOMA-IR), in pediatric patients undergoing cardiac surgery. The study will compare outcomes between children who receive an oral carbohydrate beverage prior to surgery and those who follow standard preoperative fasting protocols.

Key facts

Study ID

NCT07729280

Run by

Rifdhani Fakhrudin Nur

People needed

44

Starts

2026-08-25

Expected to finish

2026-11-01

Last updated by the study team

2026-07-27

Who can join

Age: 2 and older, up to 16. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 2-16 years.
• ASA physical status 2 or 3
• Good tolerance of enteral feeding

You may not qualify if…

• History of type 1 diabetes mellitus.
• History of thyroid insufficiency treated with thyroid medication.
• History of adrenal insufficiency treated with corticosteroids.
• History of gastroesophageal reflux disease.
• Patients receiving preoperative parenteral nutrition.
• Emergency or urgent cardiac surgery.

Where it is running

• RSUP Dr. Sardjito — Sleman, D.I. Yogyakarta, Indonesia

Full record on ClinicalTrials.gov

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