Prediction of Functional Recovery in Patients With Intracerebral Hemorrhage

Enrolling by invitation

Conditions studied: Intracranial Hemorrhage, Spontaneous

In brief

Currently, we lack sufficiently reliable tools to accurately predict, in the first few hours, the vital prognosis, functional status, and quality of life of patients with intracerebral hemorrhage (ICH). With new neurosurgical techniques and improvements in neurocritical care, it is essential to adapt therapeutic decisions to the wishes of patients and their families. Doing so based on a reliable functional prognosis will reduce arbitrariness in treatments and help avoid situations of unwanted dependency and high social and healthcare costs. This project aims to validate, in several hospitals in Spain and in real-world clinical practice, a new, easy-to-implement predictive scale that estimates the probability of functional recovery in patients with ICH in the short and long term. It will also analyze new prognostic blood biomarkers that could enhance the scale's accuracy.

Key facts

Study ID

NCT07728734

Run by

Germans Trias i Pujol Hospital

People needed

1688

Starts

2026-07-01

Expected to finish

2029-12-01

Last updated by the study team

2026-07-28

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients ≥ 18 years diagnosed with spontaneous intracranial hemorrhage (ICH) by CT scan and treated maximally within the first 24 hours.
• Prior functional independence defined as modified Rankin scale (mRS) ≤ 3.
• Time from symptom onset or last known seen well ≤ 24 hours.
• Signed informed consent by the patient or their representative.

You may not qualify if…

• Age < 18 years
• Intracranial hemorrhage secondary to trauma, ischemic stroke, or fibrinolytic or endovascular treatment.
• Spontaneous ICH with limitation of therapeutic effort (LTE) within the first 24 hours. LTE is defined as the withholding or withdrawal of potentially life-sustaining treatment and/or the initiation of comfort care measures with the expectation that the patient may die as a result. Potentially life-sustaining treatments include: orotracheal intubation and mechanical ventilation, cardiopulmonary resuscitation, and neurosurgical treatments (intracranial pressure monitoring, external ventricular drainage, hematoma evacuation, decompressive craniectomy). LTE is not considered to apply if only a do-not-resuscitate (DNR) order was established, without limitation of any other treatment.
• Prior functional dependence, defined as mRS > 3
• Time from symptom onset or last known seen well >24 hours

Where it is running

• Neurology Department, German Trias I Pujol Hospital. — Badalona, Barcelona, Spain

Full record on ClinicalTrials.gov

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