Transit Bipartition After Sleeve Gastrectomy

Starting soon · Not applicable

Conditions studied: Obesity & Overweight, Gastroesophageal Reflux (GERD), Weight Recurrence, Bariatric Surgery

In brief

This prospective, single-center study will evaluate adults undergoing revisional conversion from sleeve gastrectomy to intestinal transit bipartition. Forty participants will complete clinical, endoscopic, physiological, metabolic, hormonal, imaging, and stool assessments before surgery and during follow-up. The primary outcome is the within-participant change in solid-meal gastric emptying half-time (T½), measured by standardized scintigraphy from baseline to 6 months. Secondary and exploratory outcomes include reflux symptoms, DeMeester score and acid exposure, route-specific gastric transit, GLP-1 and ghrelin responses, glucose metabolism, fecal elastase, gut microbiota, body-weight trajectory, comorbidities, gastroileal anastomotic caliber, and safety.

Key facts

Study ID

NCT07728682

Run by

Hospital das Clínicas de Ribeirão Preto

People needed

40

Starts

2026-08-02

Expected to finish

2027-09-30

Last updated by the study team

2026-08-03

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 18 years or older;
• Previous sleeve gastrectomy for the treatment of obesity;
• Follow-up at the HCRP gastrosurgery/bariatric surgery outpatient clinic through 2026;
• Clinical evaluation supporting revisional conversion to intestinal transit bipartition;
• Willingness to undergo the new surgical procedure and provide written informed consent.

You may not qualify if…

• Liver cirrhosis;
• Absence of willingness to undergo a new surgical procedure.

Where it is running

• Hospital das Clínicas de Ribeirão Preto — Ribeirão Preto, São Paulo, Brazil

Full record on ClinicalTrials.gov

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