Endothelial Extracellular Vesicles as Biomarkers of Endothelial Activation in Pregnant Women With Hypertensive Disorders of Pregnancy

Recruiting now

Conditions studied: Hypertensive Disorder of Pregnancy, Gestational Hypertension, Preeclampsia

In brief

Hypertensive disorders of pregnancy are associated with endothelial dysfunction and increased maternal and fetal morbidity. Endothelial extracellular vesicles (EEVs) have emerged as promising biomarkers of endothelial activation; however, their relationship with blood pressure and endothelial function during pregnancy remains incompletely understood. This observational case-control study aims to compare circulating EEV concentrations between normotensive pregnant women and pregnant women with hypertensive disorders of pregnancy. The study will also investigate the associations between EEV levels, blood pressure, microvascular endothelial function assessed by laser Doppler flowmetry, and circulating biomarkers of endothelial activation. The findings may improve understanding of endothelial injury during pregnancy and support the development of non-invasive biomarkers for early detection and monitoring of hypertensive disorders of pregnancy.

Key facts

Study ID

NCT07728656

Run by

Josip Juraj Strossmayer University of Osijek

People needed

80

Starts

2026-04-01

Expected to finish

2029-09-30

Last updated by the study team

2026-07-27

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Pregnant women aged ≥18 years.
• Singleton pregnancy.
• Ability to provide written informed consent.
• Normotensive pregnancy or diagnosis of gestational hypertension or preeclampsia according to current clinical guidelines.
• Ability to comply with study procedures.

You may not qualify if…

• Chronic hypertension diagnosed before pregnancy.
• Multiple pregnancy.
• Pre-existing diabetes mellitus.
• Chronic kidney disease.
• Autoimmune disease.
• Known cardiovascular disease.
• Active infection or inflammatory disease.
• Malignancy.
• Inability or unwillingness to provide informed consent.

Where it is running

• Faculty of Medicine Osijek — Osijek, Croatia (enrolling)

Full record on ClinicalTrials.gov

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