RISE: Reducing Cancer and HIV Stigma Through Empowerment

Starting soon · Not applicable

Conditions studied: HIV, Cervical Cancer Stigma

In brief

This multilevel randomized behavioral study evaluates participant- and provider-level stigma-reduction interventions in Zambia. Participant-level intervention: Women living with cervical cancer and HIV (WLC+H ) are randomized in a 2×2 factorial design of storytelling versus neutral videos and storytelling versus neutral disclosure interventions to assess effects on quality of life, anxiety, and depressive symptoms. Provider-level intervention: Healthcare workers are randomized to storytelling or neutral videos to assess changes in stigma and compassion. The study also evaluates participant -reported stigma and satisfaction with care before and after implementation of the provider intervention.

Key facts

Study ID

NCT07728370

Run by

M.D. Anderson Cancer Center

People needed

440

Starts

2026-09-01

Expected to finish

2030-08-31

Last updated by the study team

2026-07-27

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patient-level intervention
• Women diagnosed with cervical cancer and HIV (stage I-IV)
• Receiving cancer treatment at the Cancer Disease Hospital in Zambia
• Aged 18 or above 4. Able to speak in English (the official language in Zambia) or one of four local languages (Bemba, Nyanja, Tonga, Lozi) for cultural inclusivity
• Provider-level intervention
• Employment at the Cancer Disease Hospital in Lusaka, Zambia

You may not qualify if…

• Patient-level intervention
• Inability to provide informed consent and presence of a major mental health disorder (e.g., schizophrenia or bipolar disorder), as determined by participant records or self-report.
• Provider-level intervention
• Inability to provide informed consent

Where it is running

• UT MD Anderson — Houston, Texas, United States

Full record on ClinicalTrials.gov

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