Safety, PK, and PD Comparison of UI059 and UIC202201 in Healthy Volunteers

Starting soon · Phase 1

Conditions studied: Gastro Esophageal Reflux Disorder

In brief

A randomized, open-label, multiple-dose, crossover phase 1 clinical trial to compare and evaluate the safety, pharmacokinetics and pharmacodynamics characteristics after oral administration of UI059 and UIC202201 in healthy adult volunteers

Key facts

Study ID

NCT07727629

Run by

Korea United Pharm. Inc.

People needed

60

Starts

2026-07-01

Expected to finish

2026-08-01

Last updated by the study team

2026-07-27

Who can join

Age: 19 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Healthy adult volunteers aged 19 years or older at the time of screening.
• Weight and Body Mass Index (BMI) at screening as follows:
• Body weight: ≥50.0kg for males, ≥45.0kg for females.
• BMI: ≥18.0mg/m2 and ≤ 30.0kg/m2
• Subjects who do not have congenital or chronic diseases requiring treatment and have no pathological symptoms or findings based on medical examination.
• Subjects judged suitable for the clinical trial based on laboratory tests, vital signs, physical examination, and 12-lead ECG conducted at screening.
• Subjects who test negative for H.pylori antibody at screening.
• Subjects who voluntarily decide to participate and provide written informed consent after being fully informed of and understanding the details of this clinical trial and the subject compliance requirements.

You may not qualify if…

• Current or past history of clinically significant liver, kidney, neurological, psychiatric, respiratory, endocrine, hematologic, oncologic, genitourinary, cardiovascular, gastrointestinal, or musculoskeletal diseases.
• History of gastrointestinal diseases (e.g., Crohn's disease, ulcers, acute or chronic pancreatitis) or gastrointestinal surgery (excluding simple appendectomy, hernia repair, or dental procedures) that may affect the absorption of the investigational product.
• Pregnant (positive Urine-HCG test) or breastfeeding women.
• History of clinically significant hypersensitivity (e.g., anaphylaxis or angioedema) to the investigational product ingredients, excipients, or other drugs (e.g., aspirin, penicillin-type antibiotics, macrolide antibiotics, etc.).
• Clinically significant findings on 12-lead ECG at screening, including:
• QTc>450ms(males) or >470ms(females)
• PR intervals>200ms
• QRS duration>120ms
• Clinically significant laboratory results at screening, including:
• Liver function (AST, ALT, ALP, γ-GT, and total bilirubin) exceeding 2 times the upper limit of normal (ULN).
• Serum creatinine outside the reference range, or eGFR calculated by the CKD-EPI formula < 60 mL/min/1.73m2.
• History of drug abuse or a positive response to drugs of abuse in the urine drug screen.
• Vital signs measured in a sitting position after at least 3 minutes of rest at screening:
• Systolic Blood Pressure ≤ 90 mmHg or ≥ 150 mmHg
• Diastolic Blood Pressure ≤ 60 mmHg or ≥ 100 mmHg
• Pulse Rate ≤ 40 bpm or ≥ 100 bpm
• Abnormal diet or consumption of food that may affect the absorption, distribution, metabolism, and excretion (ADME) of the investigational product.
• Use of any prescription drugs or herbal medicines within 2 weeks, or any over-the-counter (OTC) drugs or health functional foods within 10 days before the first dose (unless deemed by the investigator not to affect the PK of the investigational product).
• Use of drugs that induce or inhibit drug-metabolizing enzymes (e.g., barbiturates) within 1 month before the first dose.
• Participation and dosing in another clinical trial within 6 months before the first dose.
• Whole blood donation within 2 months, component donation within 1 month, or blood transfusion within 1 month before the first dose; or inability to refrain from donation during the study.
• Consistent alcohol consumption exceeding 21 units/week (1 unit = 10g of pure alcohol) within 6 months before the first dose, or inability to abstain from alcohol during the study.
• Smokers who averaged > 10 cigarettes/day within 3 months before the first dose, or inability to quit smoking from 48 hours before the first dose until the last PK blood collection.
• Consumption of food containing grapefruit within 72 hours before the first dose, or inability to abstain during the study.
• Consumption of food containing caffeine (coffee, tea, soda, etc.) from 48 hours before each first dose until the last PK blood collection, or inability to abstain.

Where it is running

• Chungbuk national university hospital — Cheongju-si, North Chungcheong, South Korea

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.