PCOS and Brain Health

Recruiting now

Conditions studied: PCOS

In brief

The purpose of this study is to determine how polycystic ovary syndrome (PCOS) impacts overall brain health, such as cerebral blood flow (CBF), brain structure and connectivity, and cognitive performance. 45 reproductive aged (18-45 years) individuals with ovaries, with and without PCOS, will be enrolled to complete brain structure and CBF scans via magnetic resonance imaging (MRI) over 2 testing visits and can expect to be on study for approximately 5 hours over a 1 to 3 month period.

Key facts

Study ID

NCT07727512

Run by

University of Wisconsin, Madison

People needed

45

Starts

2026-08-01

Expected to finish

2028-08-01

Last updated by the study team

2026-07-28

Who can join

Age: 18 and older, up to 45. Sex: female. Healthy volunteers: accepted.

You may not qualify if…

• Current pregnancy
• Preexisting diagnosis of type 1 diabetes
• Severe obesity (body mass index (BMI) greater than 45kg/m2)
• Preexisting diagnosis of hypertension requiring antihypertensive medication or blood pressure of greater than 160/100 on two separate occasions during clinical care
• History of neurologic disease or stroke
• History of myocardial infarction or deep venous thrombosis
• Endometriosis confirmed by prior laparoscopy
• Autoimmune conditions including lupus, multiple sclerosis, and active malignancy
• Immuno-modulating medications
• Conditions incompatible with MRI scanning, including but not limited to
• Certain implanted metal devices or foreign bodies
• Severe claustrophobia
• Post-menopausal
• Participants will be excluded if they have taken hormonal contraception or fertility medication in the last month

Where it is running

• University of Wisconsin — Madison, Wisconsin, United States (enrolling)

Full record on ClinicalTrials.gov

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