Rapid or Ultra-rapid Diagnosis of Myocardial Infarction Using High-Sensitivity Cardiac Troponin on Hospital Presentation
Starting soon · Not applicable
Conditions studied: Coronary Syndrome, Acute, Myocardial Infarction, Coronary Artery Disease, Cardiovascular Diseases, Cardiovascular Disease Acute
In brief
People with chest pain are often tested for a heart attack using a blood test called high-sensitivity cardiac troponin (hs-cTn). Traditionally, this blood test is repeated 3 hours after the first sample. Newer guidelines recommend repeating the test after 1 hour instead, which may allow patients to receive a diagnosis and leave the hospital sooner. The purpose of the DanRUSH trial is to compare these two strategies: repeating the blood test after 1 hour versus after 3 hours in adults with suspected acute coronary syndrome. The study will evaluate whether the 1-hour strategy is as safe as the 3-hour strategy while reducing the length of hospital stay. DanRUSH is a nationwide, pragmatic, cluster-randomized trial conducted in emergency- and cardiology departments across Denmark. The results will help determine the best timing for blood testing in patients with suspected heart attack and improve future care for these patients.
Key facts
- Study ID
- NCT07727135
- Run by
- Herlev and Gentofte Hospital
- People needed
- 28000
- Starts
- 2026-09-01
- Expected to finish
- 2029-02-01
- Last updated by the study team
- 2026-08-06
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Adults (≥18 years) presenting with suspected acute coronary syndrome (ACS) with a clinical indication for high-sensitivity cardiac troponin testing
You may not qualify if…
- Age <18 years.
- ST-segment elevation myocardial infarction (STEMI) identified on the presenting electrocardiogram and requiring immediate reperfusion therapy.
Where it is running
- Aalborg University Hospital — Aalborg, Denmark
- Bispebjerg & Frederiksberg Hospital — Bispebjerg, Denmark
- Esbjerg og Grindsted Sygehus — Esbjerg, Denmark
- Gødstrup Regional Hospital — Gødstrup, Denmark
- Herlev & Gentofte Hospital — Herlev, Denmark
- Nordsjællands Hospital — Hillerød, Denmark
- Amager & Hvidovre Hospital — Hvidovre, Denmark
- Nykøbing Falster County Hospital — Nykøbing Falster, Denmark
- Odense University Hospital — Odense, Denmark
- Svendborg Hospital — Svendborg, Denmark
- Central Jutland Regional Hospital (Viborg Hospital & Silkeborg Hospital) — Viborg, Denmark
Full record on ClinicalTrials.gov
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