Correlation Between Colour and Hypersensitivity of First Permanent Molars With Molar Incisor Hypomineralisation (MIH)
Recruiting now
Conditions studied: Molar Incisor Hypomineralisation
In brief
Cheese molars (MIH: molar incisor hypomineralisation) can be recognized not only by their colour abnormalities but also by their hypersensitivity. Clinical management of these teeth may become challenging by the chronic hypersensitivity, which makes various steps of a treatment, such as pain control or light curing of any type of composite restorations, difficult or even impossible, despite profound local anesthesia. Hypersensitivity can be detected by the clinician based on the patient's statements or reaction. On the other hand, colours and structural abnormalities can be easily assessed by visual inspection. The aim of this study is to determine the relationship between hypersensitivity and the colour of the enamel defect on young first permanent molars. A correlation between colour of the defect and hypersensitivity could enable early prognosis leading to preventive measures in order to delay, amplify or even avoid the onset of the symptoms. Children diagnosed with MIH on their first permanent molars of different severity are matched to children with sound molars. They are identified by the annual school dental check-up and are invited to take part in the study. The children will be invited to the university dental clinic via letter for the first appointment. Upon parental consent, the teeth will be photographed and scanned as well as investigated for hypersensitivity through a gentle air blast.
Key facts
- Study ID
- NCT07727044
- Run by
- University of Basel
- People needed
- 45
- Starts
- 2026-01-09
- Expected to finish
- 2026-10-31
- Last updated by the study team
- 2026-07-27
Who can join
Age: 5 and older, up to 8. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Children between 5 to 8 years with MIH molars with or without hypersensitivity according to the MIH-TN Index (Bekes et al 2016)
- Children with first molars in occlusion
- Children fit and healthy
You may not qualify if…
- MIH first permanent molars that have already received any kind of dental treatment
- Children diagnosed with HSPM (hypomineralised second primary molars)
- Children older than 8 years - Children younger than 5 years
- Children with any cranio-facial and/or other developmental dental defects
- Children diagnosed with parafunctions (attrition/ erosion)
- Children and/or parents who did not consent to the study
- Children with MIH teeth that show clinically visible enamel loss during the eruption
- Children without the first molars in occlusion
- Non- MIH Control Group
- Inclusion Criteria:
- Children between 5 to 8 years with no clinically affected molars
- Children fit and healthy
- Exclusion Criteria:
- Children who have already received any kind of dental treatment on their permanent or primary teeth
- Children diagnosed with MIH or any other disease of the teeth
- Children older than 8 years
- Children younger than 5 years
- Children with any cranio-facial and/or other developmental dental defects
- Children diagnosed with parafunctions (attrition/ erosion)
- Children and/or parents who did not consent to the study
Where it is running
- University Centre for Dental Medicine — Basel, Canton of Basel-City, Switzerland (enrolling)
Full record on ClinicalTrials.gov
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