Hemodynamic Changes and Trigeminocardiac Reflex During Bimaxillary Orthognathic Surgery

Recruiting now

Conditions studied: Orthognathic Surgery, Trigeminocardiac Reflex, Hemodynamic

In brief

This observational study aims to evaluate hemodynamic changes occurring during bimaxillary orthognathic surgery using routinely collected intraoperative monitoring data. Heart rate, systolic and diastolic blood pressure, mean arterial pressure, and oxygen saturation will be recorded during different stages of surgery as part of standard clinical care. The study will also evaluate the occurrence of the trigeminocardiac reflex (TCR) and its association with patient characteristics and surgical stages. No additional interventions, laboratory tests, or procedures will be performed beyond routine clinical practice. The findings may contribute to the early recognition and management of intraoperative hemodynamic changes during orthognathic surgery.

Key facts

Study ID

NCT07726251

Run by

Kırıkkale University

People needed

18

Starts

2026-06-20

Expected to finish

2027-07-20

Last updated by the study team

2026-07-28

Who can join

Age: 18 and older, up to 40. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adults aged 18-40 years.
• Patients with an indication for bimaxillary orthognathic surgery.
• Patients with complete routine intraoperative hemodynamic monitoring data.
• Patients who provide written informed consent to participate in the study.

You may not qualify if…

• Patients without an indication for bimaxillary orthognathic surgery.
• Individuals younger than 18 years or older than 40 years.
• Patients with known cardiovascular disease, including arrhythmia, heart failure, coronary artery disease, or other significant cardiovascular disorders.
• Patients with systemic diseases, including diabetes mellitus, hypertension, thyroid disorders, or other significant systemic conditions.
• Patients with diagnosed psychiatric disorders.
• Patients with incomplete or irregularly recorded intraoperative hemodynamic monitoring data.
• Individuals who refuse to participate or do not provide written informed consent.

Where it is running

• Kırıkkale Univesity Faculty of Dentistry — Kirikkale, Kırıkkale, Turkey (Türkiye) (enrolling)

Full record on ClinicalTrials.gov

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