Mantram Repetition Versus Health Education for Veterans With PTSD and Chronic Pain

Starting soon · Not applicable

Conditions studied: Stress Disorders, Post-Traumatic, Pain, Chronic

In brief

Approximately 450,000 Veterans Health Administration service users have both posttraumatic stress disorder (PTSD) and chronic pain (CP); treatments that efficiently target both PTSD and CP are limited, and new interventions should address the unique needs of Veterans with PTSD/CP. Mantram Repetition Program (MRP), a meditation-based program, appears well-suited to address these high-priority VA needs. MRP has established effectiveness for treatment of PTSD, is broadly acceptable, can be learned quickly and applied flexibly. However, rigorous testing is needed for pain-related outcomes among a PTSD/CP population. The proposed study will include a randomized controlled trial comparing the efficacy of MRP for PTSD/CP to Health Education while Living with Pain among a sample of 170 Veterans with comorbid PTSD/CP. The primary outcomes will be PTSD symptoms and pain interference. Results from this study will directly inform patient care among the nearly 4% of Veterans with PTSD/CP.

Key facts

Study ID

NCT07725588

Run by

VA Office of Research and Development

People needed

170

Starts

2027-04-01

Expected to finish

2030-09-30

Last updated by the study team

2026-07-27

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• U.S. Veteran
• Diagnosis of PTSD
• Chronic, non-malignant pain:
• (a) pain most days (> 3 days/week) for at least 6 months
• (b) average pain severity and interference with enjoyment of life and/or general
• Willing/able to engage in study activities

You may not qualify if…

• Significant current risk of suicide or homicide
• Untreated severe alcohol or substance use disorder
• Untreated/unstable serious mental health disorders, such as psychotic disorders, bipolar disorder, or serious dissociative symptoms
• Impaired mental status
• Concurrent interventions specifically targeting PTSD or CP or social functioning (e.g., couples therapy) or any meditative or mind-body intervention

Where it is running

• VA San Diego Healthcare System, San Diego, CA — San Diego, California, United States

Full record on ClinicalTrials.gov

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