Structural and Clinical Predictors of Cognitive Impairment After Surgical Treatment for Ruptured Cerebral Aneurysms

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Conditions studied: Subarachnoid Aneurysm Hemorrhage, Microsurgery, Cognitive Impairment

In brief

This study investigates the clinical and structural predictors of long-term cognitive impairment in patients who underwent microsurgical clipping for aneurysmal subarachnoid hemorrhage. Using a retrospective cohort with prospective neuropsychological and MRI assessments, it aims to identify factors associated with late cognitive deficits and improve prognostic stratification, rehabilitation planning, and long-term patient care.

Key facts

Study ID

NCT07723131

Run by

University of Campinas, Brazil

People needed

150

Starts

2026-08-01

Expected to finish

2029-12-01

Last updated by the study team

2026-07-23

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥18 years at the time of aSAH.
• Treatment by microsurgical clipping of a ruptured cerebral aneurysm.
• Survival until study recruitment.
• Ability to understand and sign informed consent.

You may not qualify if…

• Non-aneurysmal subarachnoid hemorrhage.
• Exclusively endovascular treatment.
• Previous diagnosis of dementia.
• Severe neurological or psychiatric disorders unrelated to aSAH with significant cognitive impact.
• Absolute contraindication to MRI.
• Severe aphasia preventing adequate neuropsychological evaluation.
• Incomplete clinical data.
• Inability to attend in-person assessment.

Where it is running

• Clinics Hospital - UNICAMP — Campinas, São Paulo, Brazil

Full record on ClinicalTrials.gov

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