Acute Autonomic Responses During and After BFR Training
Starting soon · Not applicable
Conditions studied: Blood Flow Restriction Exercise, Aging
In brief
The goal of this clinical trial is to compare how the body's nervous system responds to two different types of leg exercise in young and older adults. One type is low-intensity exercise with blood flow restriction (BFR) , where a cuff partially reduces blood flow to the legs during exercise. The other type is traditional high-intensity resistance training (HIRT), which uses heavier weights. The main questions it aims to answer are: Does low-intensity exercise with BFR cause less stress on the nervous system during exercise compared to high-intensity training? Does low-intensity exercise with BFR lead to faster recovery of the nervous system after exercise compared to high-intensity training? Do these responses differ between young adults and older adults? Researchers will compare low-intensity exercise with BFR to high-intensity training to see which approach is gentler on the nervous system during and after exercise. Participants will: Attend three visits to the research lab Complete a strength test on leg exercise machines Perform two separate exercise sessions: one with low-intensity exercise and BFR, and one with high-intensity training Have their heart rate, blood pressure, and heart rate variability monitored continuously during and after each exercise session
Key facts
- Study ID
- NCT07722403
- Run by
- Egas Moniz - Cooperativa de Ensino Superior, CRL
- People needed
- 48
- Starts
- 2026-10-05
- Expected to finish
- 2027-06-25
- Last updated by the study team
- 2026-07-23
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Young adults aged 18-24 years
- Older adults aged 60 years and above
- Willing and able to provide written informed consent
- Able to comply with study procedures and visit schedule
You may not qualify if…
- Medications affecting cardiac activity (e.g., beta-blockers, calcium channel blockers, antiarrhythmics)
- Tobacco use
- Sleep apnea
- Body mass index (BMI) greater than 30 kg/m²
- Regular exercise training (more than 150 minutes per week for more than 6 months)
- History of coronary heart disease
- History of stroke
- History of oncological disease
- History of major cardiovascular events
- Peripheral vascular disease
- Uncontrolled hypertension
- Diabetes mellitus
- Unstable angina
- Active kidney or liver disease
- Chronic obstructive pulmonary disease (COPD)
- Recent surgical procedure (within the last two months)
- Neurological impairments affecting exercise capacity
- Orthopedic impairments affecting exercise capacity
- Sensory impairments affecting exercise capacity
Where it is running
- Egas Moniz School of Health and Science — Almada, Monte Da Caparica, Portugal
Full record on ClinicalTrials.gov
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