Glycolytic Phenotype (vLapeak) and Magnitude of Skeletal Muscle Hypertrophy After Resistance Training

Recruiting now · Not applicable

Conditions studied: Healthy Volunteers, Muscle Hypertrophy, Glycolysis, Moderately Trainend

In brief

The HyperLa study investigates whether a person's "glycolyticness"-the efficiency with which their body uses glycolysis for energy-can predict how much their muscles will grow (hypertrophy) in response to resistance training. Participants will undergo a specialized "vLapeak" test, which measures the maximal rate of lactate accumulation during a 10-second all-out cycling sprint, to determine their individual glycolytic power. Following this initial assessment, participants will complete eight weeks of standardized, twice-weekly resistance training focused on the lower body. The study aims to determine if individuals with higher initial vLapeak values experience greater increases in muscle size compared to those with lower values. This research may help explain why people respond differently to exercise and support the development of personalized training programs.

Key facts

Study ID

NCT07721766

Run by

Technical University of Munich

People needed

120

Starts

2026-05-04

Expected to finish

2026-12-01

Last updated by the study team

2026-07-23

Who can join

Age: 18 and older, up to 39. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Body Mass Index (BMI) between 20-29 kg/m2
• No structured resistance training performed in the last twelve months.
• Maximum of four sessions per week of recreational or low-to-moderate aerobic endurance activity.
• No history of competitive strength or physique sports.

You may not qualify if…

• Diagnosed cardiovascular, pulmonary, metabolic, neuromuscular, or orthopaedic disease that contraindicates exercise.
• Positive response to any question on the PAR-Q 2025 questionnaire.
• Current use of anabolic steroids, creatine, or other substances known to strongly influence muscle hypertrophy.
• Regular engagement in shift work.
• Women who are pregnant or breastfeeding.

Where it is running

• University of Jyväskylä, Faculty of Sport and Health Sciences — Jyväskylä, Central Finland, Finland (enrolling)
• Technical University of Munich, TUM School of Medicine and Health — München, Bavaria, Germany (enrolling)
• DLR Cologne, Department of Metabolism and Human Performance — Cologne, North Rhine-Westphalia, Germany (enrolling)
• iST University of Applied Sciences — Düsseldorf, North Rhine-Westphalia, Germany (enrolling)
• TU Chemnitz, Sports Medicine and Exercise Therapy — Chemnitz, Saxony, Germany (enrolling)
• Institute for Applied Training Science (IAT) Leipzig — Leipzig, Saxony, Germany (enrolling)
• University of Limerick, Department of Physical Education and Sport Sciences (PESS) — Limerick, Limerick, Ireland (enrolling)
• Universidad Politécnica de Madrid, Facultad de Ciencias de la Actividad Física y del Deporte (INEF) — Madrid, Madrid, Spain (enrolling)

Full record on ClinicalTrials.gov

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