Intrahospital Influenza Vaccination in Patients at High Cardiovascular Risk (VACC-UP)

Starting soon · Not applicable

Conditions studied: Acute Coronary Syndrome, Heart Failure, Influenza, Human, Cardiovascular Diseases, Vaccination Refusal

In brief

The aim of this study is to evaluate the effect of offering intrahospital influenza vaccination as an adjunct to active counseling during the index hospitalization to adult patients hospitalized for acute coronary syndrome (ACS) or congestive heart failure (CHF), compared with active counseling alone, on influenza vaccination rates in patients at high cardiovascular risk. Patients are randomized 1:1 to either an offer of bedside intrahospital influenza vaccination according to the recommendations of the German Standing Vaccination Committee (STIKO) in addition to standardized active counseling (intervention group), or standardized active counseling plus the standard-of-care recommendation for ambulatory vaccination in the discharge papers (control group). The primary endpoint is the influenza vaccination rate at the end of the index season (March 31).

Key facts

Study ID

NCT07721649

Run by

Stephan Baldus

People needed

482

Starts

2026-09-01

Expected to finish

2029-06-01

Last updated by the study team

2026-07-23

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 18 years or older
• Hospitalized due to acute coronary syndrome (ACS) or congestive heart failure (CHF) and fulfilling the criteria for influenza vaccination according to the recommendations of the German Standing Vaccination Committee (STIKO)
• Written informed consent

You may not qualify if…

• Already received seasonal influenza vaccination in the current season, based on self-reported vaccination status and/or vaccination certificate
• Laboratory-confirmed active influenza infection during the index hospitalization
• Contraindication for vaccination (e.g., known allergy)
• Inability to provide written informed consent

Where it is running

• Clinic III for Internal Medicine, University Hospital of Cologne — Cologne, Germany
• Department of Cardiology, University Heart and Vascular Centre Hamburg — Hamburg, Germany

Full record on ClinicalTrials.gov

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