Nephrostomy Tract Infiltration for Pain Control After PCNL

Recruiting now · Not applicable

Conditions studied: Postoperative Pain, Kidney Calculi

In brief

This prospective, randomized, controlled clinical trial aims to evaluate the effectiveness of nephrostomy tract local anesthetic infiltration for postoperative pain control in patients undergoing prone percutaneous nephrolithotomy. Eligible patients will be randomly assigned to either a control group receiving standard systemic postoperative analgesia or an intervention group receiving standard analgesia plus infiltration of 20 mL of 0.25% bupivacaine along the nephrostomy tract at the end of surgery. Postoperative pain will be assessed using the Visual Analog Scale at 1, 6, 12, and 24 hours. Secondary outcomes will include time to first analgesic requirement, total opioid consumption during the first 24 hours, need for rescue analgesia, time to mobilization, length of hospital stay, and treatment-related complications. The study is designed to determine whether nephrostomy tract infiltration provides a simple, safe, and effective adjunct for reducing pain and analgesic consumption after percutaneous nephrolithotomy.

Key facts

Study ID

NCT07721571

Run by

Hitit University

People needed

60

Starts

2026-07-17

Expected to finish

2027-06-11

Last updated by the study team

2026-07-23

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adults aged 18 to 75 years
• Scheduled to undergo elective percutaneous nephrolithotomy in the prone position
• Classified as American Society of Anesthesiologists physical status I-III
• Able to understand and complete postoperative pain assessments using the Visual Analog Scale
• Willing to participate in the study
• Provision of written informed consent

You may not qualify if…

• Known allergy or hypersensitivity to bupivacaine or other local anesthetic agents Coagulopathy or clinically significant bleeding disorder Chronic opioid use History of a neurological disorder that may affect pain perception or assessment Neurological or psychiatric condition preventing reliable postoperative pain assessment Active urinary tract infection or sepsis American Society of Anesthesiologists physical status IV or higher Requirement for multiple percutaneous access tracts Bilateral percutaneous nephrolithotomy Requirement for postoperative intensive care Refusal or inability to provide written informed consent

Where it is running

• Department of Urology, Hitit University Çorum Erol Olçok Training and Research Hospital, Çorum, Türkiye — Çorum, Çorum, Turkey (Türkiye) (enrolling)

Full record on ClinicalTrials.gov

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