A Prospective Clinical Study Observed the Effects of Tubeless Anesthesia Method That Preserves Spontaneous Breathing and the Double-lumen Bronchial Intubation on the Brain Health During the Perioperative Period

Starting soon

Conditions studied: Brain Health

In brief

This project conducts a prospective cohort study. By using multiple questionnaire survey methods such as the Pittsburgh Sleep Quality Index (PSQI) electronic wristband, QOR15, Pain Catastrophizing Scale (PCS), European Five-Dimensional Health Scale (EQ-5D), Revised American Pain Society Patient Follow-up Questionnaire (APS-POQ-R), Mini-Mental State Examination (MMSE), as well as perioperative stress and related indicators, hypothalamic-pituitary-adrenal axis (HPA) endocrine indicators, sublingual microcirculation, electroencephalogram, etc., comprehensive assessment is made of the correlations between the two different anesthesia methods of Tubeless retention of spontaneous breathing and double-lumen bronchial intubation and postoperative sleep, chronic pain and cognitive function, to construct a perioperative brain health safety system to improve prognosis; at the same time, optimize the perioperative sedation and analgesia plan and promote the postoperative brain health recovery of patients.

Key facts

Study ID

NCT07721038

Run by

Guangzhou Medical University

People needed

400

Starts

2026-07-20

Expected to finish

2028-12-31

Last updated by the study team

2026-07-22

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patient age: 18 - 75 years old
• Patients meeting the standards of the American Society of Anesthesiologists (ASA) I-III grade and the New York Heart Association (NYHA) I-II class
• Body Mass Index (BMI) < 30 kg/m2
• Intraoperative blood loss less than 300 ml
• No severe cardiac or pulmonary dysfunction [first-second forced vital capacity (FEV1%) predicted value] > 50%, ejection fraction (EF) > 50%
• No contraindications related to paravertebral nerve block and intercostal nerve block
• Able to sign the informed consent form and possess communication, reading and writing abilities
• Postoperative hospital stay of at least one day
• No preoperative sleep disorders, no cognitive dysfunction (PSQI ≤ 10 points, PCS ≤ 38 points, MMSE > 27 points)

You may not qualify if…

• Already diagnosed with a mental disorder or had a preoperative Mini-Mental State Examination (MMSE) score of less than 27
• History of opioid abuse
• Patients who were admitted to the ICU after surgery
• Have severe cardiovascular, respiratory diseases
• Experienced critical rescue during or after the surgery
• Complicated with coagulation dysfunction, severe hypoxia or hypercapnia, or liver and kidney dysfunction
• Difficult airway management
• Changed anesthetic agent or surgical plan
• Severe lacunar cerebral infarction, ischemic stroke or other neurological diseases
• Changed anesthetic agent or surgical plan during the surgery;

Where it is running

• the First Affiliated Hospital of Guangzhou Medical University — Guangzhou, Guangdong, China

Full record on ClinicalTrials.gov

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