ORI-Guided Oxygen Therapy During One-Lung Ventilation

Starting soon · Not applicable

Conditions studied: Thoracic Surgery With One-lung Ventilation

In brief

High inspired oxygen concentrations (FiO₂) are commonly administered during general anesthesia to prevent hypoxemia. However, excessive oxygen administration may result in hyperoxemia, which has been associated with impaired hypoxic pulmonary vasoconstriction, increased oxidative stress, ventilation-perfusion mismatch, and postoperative pulmonary complications. During one-lung ventilation (OLV) for thoracic surgery, higher FiO₂ is often required because of increased intrapulmonary shunting, making hyperoxemia a frequent occurrence. The Oxygen Reserve Index (ORI) is a noninvasive pulse oximetry-derived parameter that reflects moderate hyperoxemia (PaO₂ approximately 100-200 mmHg) and may facilitate more precise oxygen titration than pulse oximetry alone.

Key facts

Study ID

NCT07720778

Run by

Konkuk University Medical Center

People needed

58

Starts

2026-08-01

Expected to finish

2028-04-30

Last updated by the study team

2026-07-22

Who can join

Age: 19 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adults aged ≥19 years
• Scheduled for elective lung surgery requiring one-lung ventilation
• Written informed consent

You may not qualify if…

• Severe pulmonary hypertension.
• Left ventricular systolic dysfunction.
• Withdrawal Criteria:
• The participant or legally authorized representative requests withdrawal from the study.
• An adverse event occurs that precludes continued participation in the study.
• The planned surgery or study procedures are not performed (e.g., ORI monitoring is not applied or arterial blood gas analysis is not performed).
• Perfusion Index is less than 2 during the study.
• A major violation of the inclusion or exclusion criteria is identified after enrollment.
• The participant fails to comply with the study protocol, potentially affecting the validity of the study outcomes.
• Continued participation is considered not to be in the participant's best interest.
• In the investigator's judgment, any other condition arises that makes continued participation inappropriate.

Where it is running

• Konkuk University Medical Center — Seoul, Gwangjin-gu, South Korea

Full record on ClinicalTrials.gov

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