COLOFLOW: Laser Speckle Contrast Imaging Versus Near-infrared Fluorescence Imaging With Indocyanine Green
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Conditions studied: Leakage, Anastomotic, Colon Cancer, Colon Anastomosis, Colon and Rectal Cancer, Colon Benign Tumor, Colon and Rectal Diseases, Laser Speckle Contrast Imaging, Indocyanine Green (ICG), Near-Infrared Spectroscopy
In brief
COLOFLOW is a prospective observational study investigating whether Laser Speckle Contrast Imaging (LSCI), a dye-free and objective perfusion imaging technique, corresponds with the currently used subjective assessment of indocyanine green (ICG) fluorescence during colorectal surgery. In approximately 30 patients undergoing elective colon or rectal resection with primary anastomosis, both imaging modalities will be performed intraoperatively. The surgeons will base their clinical decisions solely on standard ICG fluorescence imaging, while LSCI measurements are collected for research purposes and do not influence treatment. Postoperatively, quantitative ICG parameters will be analysed and compared with LSCI perfusion maps to determine whether objective ICG analysis improves agreement with LSCI over subjective interpretation alone. In addition, the study will evaluate the feasibility of using the PerfusiX-IGS LSCI system during open colorectal surgery and describe postoperative outcomes, including anastomotic leakage. The ultimate goal is to contribute to more objective and standardized perfusion assessment during colorectal surgery
Key facts
- Study ID
- NCT07720505
- Run by
- Leiden University Medical Center
- People needed
- 30
- Starts
- 2026-08-01
- Expected to finish
- 2027-09-30
- Last updated by the study team
- 2026-07-22
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Adults ≥18 years.
- Undergoing elective colon resection with primary anastomosis.
- Able to provide consent for postoperative analysis of intraoperative imaging
You may not qualify if…
- Palliative surgery.
- Factors that severely limit intraoperative visualization (per investigator judgement).
- Conditions interfering with perfusion assessment (e.g., severe peripheral vascular compromise).
Full record on ClinicalTrials.gov
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