The Effect of Intradialytic Exercise on Postural Abnormalities

Starting soon · Not applicable

Conditions studied: End-Stage Renal Disease, Hemodialysis Complication

In brief

This randomized, assessor-blinded controlled trial will evaluate the preliminary efficacy and safety of a 12-week supervised intradialytic multimodal exercise program for improving postural abnormalities in adults receiving maintenance hemodialysis. Participants will be randomized to either supervised intradialytic exercise plus usual care or usual care alone. The exercise program will be performed three times per week during scheduled hemodialysis sessions and will include postural correction exercises, resistance-band strengthening, core stabilization, stretching, breathing exercises, and seated aerobic cycling. The primary outcome will be change in thoracic kyphosis angle from baseline to Week 12. Secondary outcomes will include craniovertebral angle, balance, mobility, functional exercise capacity, gait speed, physical activity level, adherence, and adverse events. The findings may provide preliminary evidence on the feasibility, safety, and potential clinical value of incorporating postural correction exercises into routine hemodialysis care.

Key facts

Study ID: NCT07720401
Run by: Pardis Specialized Wellness Institute
People needed: 98
Starts: 2026-07-25
Expected to finish: 2026-11-01
Last updated by the study team: 2026-07-27

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Age 18-80 years
Diagnosed with ESRD and receiving stable maintenance hemodialysis for at least 3 months at the participating center, with a dialysis frequency of three sessions per week
Confirmed presence of at least one postural abnormality (hyperkyphosis ≥53° in women or ≥55° in men, or CVA <53°) assessed at screening
Written informed consent obtained, indicating decision-making capacity and willingness to participate
Medical clearance from attending nephrologist to participate in supervised exercise during dialysis
Ability to sit upright in a dialysis chair and perform seated or supported standing exercises
Ability to communicate in Persian and understand study instructions

You may not qualify if…

Unstable cardiovascular status, including recent (within 3 months) myocardial infarction, unstable angina, decompensated congestive heart failure (NYHA Class III-IV), or uncontrolled arrhythmia
Active infection, acute febrile illness, or acute medical condition requiring hospitalization
Hemodynamic instability defined as systolic blood pressure <90 mmHg or >200 mmHg, or severe orthostatic hypotension, at screening or prior to exercise sessions
Uncontrolled diabetes mellitus with labile glycemic control (blood glucose <4 mmol/L or >22 mmol/L at dialysis session start)
Severe musculoskeletal pain at rest or with minimal activity (Numeric Pain Rating Scale ≥7/10) that would preclude exercise participation
Inability to perform seated exercises, walk independently, or maintain upright posture; severe neurological disability
Recent fracture (within 6 months) of vertebral column, pelvis, or lower extremities
Severe peripheral neuropathy or vascular disease (ABI <0.6) precluding lower limb exercise
Dyspnea at rest or with activities of daily living corresponding to NYHA Class IV
Participation in a structured exercise program targeting postural correction, resistance, or balance training ≥3 times per week in the preceding 3 months
Severe cognitive impairment (MMSE <18) preventing informed consent or adherence to exercise instruction
Pregnancy or planned pregnancy during the study period
Life expectancy <6 months as determined by the attending nephrologist
Scheduled kidney transplantation within the study period

Where it is running

Pardis specialized wellness institute — Isfahan, Iran

Full record on ClinicalTrials.gov

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