AMAZE 9: A Research Study Investigating How Well Zenagamtide Tablets Help People With Excess Body Weight Lose Weight

Starting soon · Phase 3 · Has a placebo group

Conditions studied: Overweight, Obesity

In brief

The purpose of this clinical study is to find out if zenagamtide is safe and effective for treating people who have excess body weight. There are 2 study treatments in this study taken as oral tablets once a day. Participants will either get zenagamtide (the treatment being tested) or Placebo (treatment that has no active medicine in it). Which treatment participants get is decided by chance.

Key facts

Study ID

NCT07720271

Run by

Novo Nordisk A/S

People needed

950

Starts

2026-09-01

Expected to finish

2028-08-22

Last updated by the study team

2026-07-22

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Male or female (sex at birth).
• Age 18 and older (both inclusive) at time of signing the informed consent.

You may not qualify if…

• Glycated haemoglobin (HbA1c) more than or equal to (≥) 6.5% [48 millimoles per mole (mmol/mol)] as measured by the central laboratory at screening.
• History of type 1 or type 2 diabetes mellitus as declared by the participant or reported in the medical records.
• Treatment with glucagon-like peptide-1 (GLP-1) receptor agonists (RA), dual GLP-1/gastric inhibitory peptide (GIP) RAs (or any other GLP-1 based treatment) or amylin analogues before screening.

Where it is running

• Pinnacle Research Group LLC — Anniston, Alabama, United States
• Univ of Alabama Birmingham — Birmingham, Alabama, United States
• Chambliss Clinical Trials LLC — Montgomery, Alabama, United States
• Providence Medical Foundation — Fullerton, California, United States
• Torrance Clinical Research Institute, Inc. — Lomita, California, United States
• Diablo Clinical Research, Inc. — Walnut Creek, California, United States
• Univ of Colorado at Denver — Aurora, Colorado, United States
• ERG Holding Company, LLC / Evolution Research Group, LLC — Delray Beach, Florida, United States
• Northeast Research Institute — Fleming Island, Florida, United States
• Miguel Rebollar PA — Hialeah, Florida, United States
• Jacksonville Ctr Clin Res — Jacksonville, Florida, United States
• South Broward Research LLC — Miramar, Florida, United States
• Clinical Neuroscience Solution — Orlando, Florida, United States
• Florida Institute for Clinical Research, LLC — Orlando, Florida, United States
• Oviedo Medical Research, LLC — Oviedo, Florida, United States
• Hope Clin Res & Wellness — Conyers, Georgia, United States
• East West Medical Research Institute_Honolulu — Honolulu, Hawaii, United States
• Great Lakes Clinical Trials — Chicago, Illinois, United States
• Clinical Investigation Spec Gurnee — Gurnee, Illinois, United States
• Endeavor Health — Skokie, Illinois, United States
• Evanston Premier Hlthcr Res — Skokie, Illinois, United States
• Midwest Inst For Clin Res — Indianapolis, Indiana, United States
• Northern Pines Hlth Ctr, PC — Buckley, Michigan, United States
• StudyMetrix Research LLC — City of Saint Peters, Missouri, United States
• Palm Research Center Inc. — Las Vegas, Nevada, United States

Full record on ClinicalTrials.gov

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