Ultrasound Assessment of Joint Health in Patients With Mild Hemophilia (Factor Levels 5-40%)
Starting soon · Not applicable
Conditions studied: Mild Hemophilia
In brief
Currently, few recommendations exist for patients with mild hemophilia, who represent approximately 60% of the hemophilia population. This study aims to provide objective data on joint health in these patients, which are currently limited compared to those with moderate or severe hemophilia. The use of joint ultrasound in mild hemophilia could allow early, asymptomatic detection of joint damage, support tailored management including patient education, and ultimately improve quality of life. The study will also explore the correlation between coagulation factor levels (FVIII or FIX) and other indicators of joint health in France.
Key facts
- Study ID
- NCT07719647
- Run by
- Assistance Publique - Hôpitaux de Paris
- People needed
- 150
- Starts
- 2026-09-01
- Expected to finish
- 2027-09-01
- Last updated by the study team
- 2026-07-22
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Adult (≥18 years old) with congenital mild hemophilia, defined as historical coagulation factor level >5% and <40% (FVIII or FIX).
- Affiliated with a social security system.
- Provided written informed consent to participate in the study.
You may not qualify if…
- Patient on prophylactic treatment, defined as at least one of the following:
- o. ≥5 factor concentrate injections per month for a period of more than 6 months o. Treatment with emicizumab o. Last factor concentrate injection within the past 28 days
- Patient with acquired hemophilia.
- Patient with uncontrolled chronic rheumatologic disease, such as rheumatoid arthritis, inflammatory spondyloarthropathies, or microcrystalline arthritis.
- Known pregnancy or breastfeeding.
- Patient deprived of liberty or under legal guardianship or conservatorship.
Where it is running
- Hôpital Necker Enfants malades — Paris, Île-de-France Region, France
Full record on ClinicalTrials.gov
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