Eco-guided Neuromodulation of the Femoral Nerve on the Performance of Amateur Athletes.

Recruiting now · Not applicable · Has a placebo group

Conditions studied: Healthy Volunteers, Neuromuscular Function

In brief

This randomized crossover study aims to evaluate whether different percutaneous electrical nerve stimulation (PENS) protocols produce changes in neuromuscular performance in healthy adults. PENS involves the ultrasound-guided application of an electrical current through a needle to modulate motor neuron excitability. Each participant will undergo five intervention sessions: (1) a long-term potentiation (LTP)-based protocol with impulse trains, (2) a 10 Hz protocol with 10 s stimulation and 10 s rest repeated ten times, (3) a 5-55 protocol with 100 Hz stimulation for 5 s followed by 55 s rest repeated five times, (4) a high-intensity burst (HIB) protocol applied at a high current intensity close to 1000 mA and repeated three times, and (5) a placebo condition. All interventions will be applied bilaterally by an experienced physiotherapist under ultrasound guidance, with a two-week washout between sessions. The objective of this trial is to assess whether these stimulation patterns produce measurable changes in squat execution velocity, jump performance, and quadriceps strength. The findings may help identify the most effective stimulation strategy for enhancing neuromuscular performance.

Key facts

Study ID

NCT07719179

Run by

Universitat Internacional de Catalunya

People needed

23

Starts

2026-09-01

Expected to finish

2026-09-30

Last updated by the study team

2026-07-22

Who can join

Age: 18 and older, up to 30. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Athletes aged between 18 and 30 years.
• Familiarized with performing barbell back squats using an Olympic bar.
• Engaged in regular training at least three times per week during the last six months.
• Able to perform squat and jump tests safely.
• Provided written informed consent to participate in the study.

You may not qualify if…

• Sports injury within the last two months or current inability to perform physical activity.
• Inability to understand or follow the instructions provided by the therapist.
• Participation in another research study during the same period.
• Belonephobia (fear of needles).
• Ongoing medical or pharmacological treatment that could interfere with neuromuscular performance (e.g., anticonvulsants, antidepressants, or similar medications).

Where it is running

• Universitat Internacional de Catalunya — Sant Cugat del Vallès, Barcelona, Spain (enrolling)

Full record on ClinicalTrials.gov

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