Psilocybin Effects on Healthy Aging Biomarkers and Purpose in Life
Starting soon · Phase 1
Conditions studied: Aging, Longevity, Biomarkers of Aging
In brief
The LONG-LIFE study is a randomized Phase I, dose-ranging trial designed to evaluate whether psilocybin impacts aging-related biomarkers, cognitive function, and purpose/meaning in life in medically stable older adults. Up to 50 participants will be enrolled aged 60-80 who will be randomized with equal allocation to one of four intervention groups: (1) receipt of one 25 mg dose of psilocybin; (2) receipt of two 25 mg doses of psilocybin separated by four weeks; (3) receipt of three 25 mg doses, with each dose separated by four weeks; or (4) wait-list comparator condition that does not receive psilocybin. Biomarkers of aging, cognitive performance, and behavioral measures will be assessed at baseline and longitudinally over a 12-month follow-up period. The primary endpoint occurs at the Week 16 visit. Participants randomized to the wait-list condition will be offered a single 25 mg dose of psilocybin following conclusion of the 12-month follow-up period. Findings from this Phase I study will inform dose selection for a Phase II study should results indicate a potential impact of psilocybin on relevant study endpoints.
Key facts
- Study ID
- NCT07719088
- Run by
- Charles Raison
- People needed
- 50
- Starts
- 2026-12-01
- Expected to finish
- 2028-12-01
- Last updated by the study team
- 2026-07-24
Who can join
Age: 60 and older, up to 80. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- English speaking and able to provide informed consent and complete study procedures
- Medically healthy, as determined by the screening physician, with no significant medical conditions that would interfere with participation or affect the safety of the subject.
You may not qualify if…
- History or presence of any psychiatric or medical condition that, in the opinion of the investigator, could pose a safety risk, interfere with participation, or confound study results.
- Abnormal ECG at screening that may increase risk during participation (e.g., prolonged QTc, arrhythmias, or other clinically significant findings as determined by the study physician).
- Unwilling or unable to discontinue medications that may interfere with study participation, as determined by the investigator.
Where it is running
- Vail Health Behavioral Health — Edwards, Colorado, United States
Full record on ClinicalTrials.gov
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