5 Versus 10 mcg Norepinephrine Bolus in Treatment of Postinduction and Early Intraoperative Hypotension in Emergency Abdominal Surgery

Recruiting now · Not applicable

Conditions studied: Hypotension on Induction, Emergency Surgery, Norepinephrine

In brief

Postinduction hypotension is a frequent intraoperative complication, particularly in emergency abdominal surgery due to factors such as sepsis, hypovolemia, and limited preoperative cardiac assessment. Because it can lead to serious organ injury, prompt prevention and management are essential. Vasopressors, including ephedrine, phenylephrine, and norepinephrine, are commonly used, with NE gaining interest as an intraoperative bolus despite uncertainty about the optimal dose in general surgery population The aim of this study is to compare 5 mcg to 10 mcg norepinephrine bolus for treatment of postinduction hypotension and early intraoperative in emergency abdominal surgery.

Key facts

Study ID

NCT07719075

Run by

Cairo University

People needed

136

Starts

2026-08-04

Expected to finish

2026-12-01

Last updated by the study team

2026-08-05

Who can join

Age: 21 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult patients, American Society of anesthesiologists (ASA) I-III undergoing emergency abdominal surgery

You may not qualify if…

• Severe cardiac morbidities (impaired contractility with ejection fraction < 45%, heart block, arrhythmias, tight valvular lesions)
• Patients on vasopressor infusion,
• Pregnant or lactating women,
• Allergy of any of the study drugs

Where it is running

• Cairo University — Cairo, Cairo Governorate, Egypt (enrolling)

Full record on ClinicalTrials.gov

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