Neuromodulation for Behavioral Changes in Neurological Disorders

Starting soon · Not applicable

Conditions studied: Dementia

In brief

The purpose of this study is to see if a focused ultrasound neuromodulation can be safely and effectively used to treat symptoms of emotional dysregulation such as agitation, irritability and anxiety

Key facts

Study ID

NCT07718906

Run by

West Virginia University

People needed

15

Starts

2026-07-25

Expected to finish

2028-12-30

Last updated by the study team

2026-07-22

Who can join

Age: 45 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may not qualify if…

• Moderate to severe dementia (i.e., beyond mild stage).
• Clinically significant MRI abnormality that may jeopardize participant safety, study conduct, or confound diagnostic assessments.
• History of clinically significant neurological disorder other than the qualifying dementia diagnosis that could confound evaluation or increase risk.
• Major psychiatric disorder that would interfere with participation or safety, including psychosis, active suicidal ideation, or severe mood/anxiety disorder requiring immediate intervention.
• Elevated suicide risk with History of medically verified suicide attempt within the past year.
• Use of medications that significantly lower the seizure threshold or interfere with neuromodulation safety, as determined by the study physician.
• Use of investigational drugs or participation in another interventional clinical trial within 30 days prior to screening.
• Any condition that, in the opinion of the investigator, would interfere with study participation, safety, or interpretation of results.

Where it is running

• WVU Rockefeller Neuroscience Institute — Morgantown, West Virginia, United States

Full record on ClinicalTrials.gov

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