CITE: Clinical Inference Tethered to Evidence - a Retrieve-and-verify Layer for AI Care Plans

Starting soon · Not applicable

Conditions studied: Quality of Health Care, Patient Safety, Clinical Decision Support

In brief

This trial evaluates CITE, a retrieve-and-verify layer that audits an AI-generated care plan against a full-text evidence corpus and flags patient-specific codifiable safety hazards to the clinician. The co-primary outcomes are how accurately CITE flags these hazards (sensitivity and specificity versus blinded clinician adjudication) and its clinician alert burden and acceptance, compared with AI care plans using safety guardrails alone and with unassisted clinician care, in Medicaid primary care.

Key facts

Study ID

NCT07718893

Run by

Waymark

People needed

240

Starts

2026-09-01

Expected to finish

2027-09-01

Last updated by the study team

2026-07-22

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 18 years or older.
• Medicaid-enrolled and attributed to a participating Waymark primary care site.
• Primary care encounter that requires clinical reasoning (not administrative-only).
• English-language clinical documentation.

You may not qualify if…

• Age less than 18 years.
• Hospice or palliative-care-exclusive care plan.
• Administrative-only or pharmacy-only encounter that does not surface a clinical decision to the supervising clinician.
• Encounter where the supervising clinician is the principal investigator.
• Enrollment in a competing AI-safety study within the prior 90 days.

Full record on ClinicalTrials.gov

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