Early Postoperative L-arginine and Acute Kidney Injury After Cardiac Surgery

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Conditions studied: Acute Kidney Injury

In brief

Acute kidney injury (AKI) is common after cardiac surgery, yet effective protective strategies remain limited. L-arginine is the substrate for endogenous nitric oxide (NO) synthesis and may improve renal perfusion and endothelial function. investigators emulated a target trial to evaluate whether early perioperative L-arginine was associated with a lower risk of AKI after cardiac surgery.

Key facts

Study ID

NCT07718373

Run by

Xijing Hospital

People needed

5000

Starts

2026-07-20

Expected to finish

2026-08-20

Last updated by the study team

2026-08-10

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• ·adults admitted to the ICU after CPB-assisted cardiac surgery

You may not qualify if…

• congenital heart disease,
• surgery requiring deep hypothermic circulatory arrest,
• a preoperative baseline estimated glomerular filtration rate (eGFR) below 30 mL/min/1.73 m²,
• AKI already present prior to ICU admission

Full record on ClinicalTrials.gov

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