Effect of Thoracic Mobilization in People With Central Obesity

Starting soon · Not applicable

Conditions studied: Central Obesity, Ventilatory Function

In brief

The goal of this clinical trial is to learn whether Mulligan thoracic mobilization in extension improves ventilatory functions and chest wall expansion in adults with central obesity. It will also evaluate whether adding Mulligan thoracic mobilization to a low-carbohydrate diet and aerobic exercise provides greater benefits than diet and exercise alone. The main questions it aims to answer are: Does Mulligan thoracic mobilization improve ventilatory functions (FVC, FEV₁, FEV₁/FVC ratio, and MVV) in adults with central obesity? Does Mulligan thoracic mobilization improve chest wall expansion, functional capacity, and health-related quality of life? Researchers will compare Mulligan thoracic mobilization combined with a low-carbohydrate diet and aerobic exercise to a low-carbohydrate diet and aerobic exercise alone to determine whether the addition of thoracic mobilization improves respiratory outcomes. Participants will: Be randomly assigned to either the intervention group or the control group. Receive an individualized low-carbohydrate diet and supervised aerobic exercise for 8 weeks. Receive Mulligan thoracic mobilization in extension five times per week for 8 weeks if assigned to the intervention group. Undergo assessments of ventilatory functions, chest wall expansion, functional capacity, and quality of life before and after the intervention.

Key facts

Study ID

NCT07718178

Run by

Cairo University

People needed

60

Starts

2026-07-25

Expected to finish

2027-02-10

Last updated by the study team

2026-07-29

Who can join

Age: 25 and older, up to 35. Sex: male. Healthy volunteers: not accepted.

You may qualify if…

• Males aged 25-35 years.
• Presence of central obesity, defined as:
• Waist circumference ≥102 cm in males.
• Waist-hip ratio (WHR) ≥0.90 in males.
• BMI from 30-39.9 kg/m².
• Willing to comply with conventional physiotherapy (diet and exercise) and mobilization programs.
• Medically stable individuals with a restrictive lung pattern (Normal FEV₁/FVC ratio and FVC < 80% of predicted).
• Low level physical activity (using the International Physical Activity Questionnaire-Short Version).
• Non-smokers.

You may not qualify if…

• Diagnosed COPD, asthma, or other chronic respiratory diseases.
• Recent thoracic spine or rib injury/surgery.
• Cardiovascular instability or uncontrolled hypertension.
• Contraindications to manual therapy (e.g., osteoporosis, rib fractures, or spinal tumors).
• Participation in any structured weight loss program or exercise regimen in the past 6 months.
• History of bariatric surgery (e.g., gastric sleeve, gastric bypass).
• Use of medications that affect body weight or metabolism (e.g., corticosteroids, antipsychotics, weight loss drugs).
• Neurological or musculoskeletal conditions that limit mobility or exercise participation and interfere with gait.
• Any acute respiratory infections in the past 6 weeks.

Full record on ClinicalTrials.gov

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